治疗包括非手术破坏（例如冷冻疗法）、局部和全身化疗、传统手术切除以及 Mohs 显微描记手术。
皮肤鳞状细胞癌 (cutaneous squamous cell carcinoma, SCC) 是皮肤不典型、变形的角质形成细胞的恶性增生。其范围从原位肿瘤（也被称为 Bowen 病）到侵袭性肿瘤和转移性疾病不等。 皮肤鳞状细胞癌的前驱病变被称为光化（或阳光损伤）角化病。
Keyoumars Soltani, MD
Department of Medicine
Director of Immunopathology
Laboratory Section of Dermatology
The University of Chicago
KS declares that he has no competing interests.
Adaobi Nwaneshiudu Obasi, MD, PhD, FAAD
Medical Director, Dermatologist, and Dermatopathologist
Cutis Wellness Dermatology & Dermatopathology, PLLC
University of the Incarnate Word
Department of Family Medicine
AIN declares that she has no competing interests.
Prof K. Soltani and Dr A. I. Nwaneshiudu would like to gratefully acknowledge Dr Carlos Paz and Dr Jessica M. Sheehan, the previous co-contributors to this topic. CP and JMS declare that they have no competing interests.
Nanette Silverberg, MD
Clinical Professor of Dermatology
Columbia University College of Physicians and Surgeons
New York City
NS declares that she has no competing interests.
Iris Aronson, MD
Department of Dermatology
University of Illinois
IA declares that she has no competing interests.
Keyvan Nouri, MD
Professor of Dermatology & Otolaryngology
Director of Mohs, Dermatologic & Laser Surgery
Director of Surgical Training
Department of Dermatology & Cutaneous Surgery
University of Miami
KN declares that he has no competing interests.
Jane McGregor, MA, MB, BChir, MRCP, MD
Senior Lecturer and Honorary Consultant Dermatologist (Barts and the London NHS Trust)
Institute of Cellular and Molecular Science
JMG declares that she has no competing interests.