最近审阅: 24 十月 2020
最近更新: 03 七月 2019

小结

定义

病史和体格检查

其他诊断因素

  • 子宫包块、宫体固定或附件区包块均提示宫外转移。
  • 绝经前女性月经异常或异常阴道出血
  • 疼痛(腹部或盆腔)和体重减轻
  • 转移性疾病的症状
  • 转移性疾病的体征

危险因素

  • 超重和肥胖
  • 缺乏运动
  • 年龄>50 岁
  • 子宫内膜增生
  • 无拮抗的内源性雌激素
  • 无拮抗的外源性雌激素
  • 他莫昔芬治疗(绝经后女性)
  • 胰岛素抵抗
  • 子宫内膜癌家族史
  • 乳腺癌或卵巢癌家族史
  • 遗传性非息肉性结肠癌(Lynch 综合征)家族史
  • PTEN 综合征家族史
  • 未孕未产
  • 多囊卵巢综合征
  • 放射治疗
  • 白种人

诊断性检查

首要检查

  • (经阴道)盆腔超声
  • 门诊子宫内膜活检(伴或不伴门诊子宫切除术)和组织病理学检查
  • 宫腔镜、诊断性刮宫 (D&C) 及组织病理学检查
  • Pap 涂片
  • 全血细胞计数 (FBC)
更多 首要检查

需考虑的检查

  • 血清 CA-125 水平
  • 盐水灌注宫腔声学造影
  • 尿素和肌酐(肾功能检测)
  • 肝功能检查 (LFT)
  • 胸部 X 线检查
  • 胸部、腹部和盆腔 CT 扫描
  • 子宫、盆腔及腹部 MRI 检查
  • PET/CT 扫描
更多 需考虑的检查

治疗流程

撰稿人

Alexander B. Olawaiye

Associate Professor

Division of Gynecologic Oncology

Department of Obstetrics, Gynecology, and Reproductive Sciences

Magee-Womens Hospital of UPMC

University of Pittsburgh School of Medicine

Pittsburgh

PA

利益声明

ABO declares that he has no competing interests.

Richard T. Penson

Clinical Director

Medical Gynecologic Oncology

Division of Hematology Oncology

Massachusetts General Hospital

Boston

MA

利益声明

RTP declares that he is on the scientific advisory boards of: Genentech, Inc., AstraZeneca, Endocyte, Inc., Eisai Inc., Vascular Biogenics Ltd, Baxalta Oncology, AbbVie, Clovis Oncology, Roche, and Merck. RTP receives research funding from: Genentech, Inc., ImClone Systems, Inc., Endocyte, Inc., AstraZeneca., Eisai Inc., Amgen Inc., and Vascular Biogenics Ltd. RTP was an expert witness for Aventis Pharma S.A. Vs. Apotex Inc in 2009. RTP has received royalties from: BMJ, Blackwell Publishing Medicine at a glance, and UpToDate Advance Medical: Second Medical Opinion. 

Larissa J. Lee

Assistant Professor

Department of Radiation Oncology

Brigham and Women’s Hospital/Dana-Farber Cancer Institute

Boston

MA

利益声明

LJL receives research funding from the Koch Institute at the Massachusetts Institute of Technology and Dana-Farber Cancer Institute. LJL is also the Principal Investigator of an immunotherapy and radiation trial sponsored by AstraZeneca.

Dr Alexander B. Olawaiye, Dr Richard T. Penson, and Dr Larissa J. Lee would like to gratefully acknowledge Dr Neil S. Horowitz and Dr Anthony H. Russell, previous contributors to this topic.

利益声明

NSH and AHR declare that they have no competing interests.

同行评议者展开全部内容

Associate Professor/Chief

Gynecologic Oncology

S/M Obstetrics & Gynecology (UCD)

University of Colorado Health Sciences Center

Aurora

CO

利益声明

SAD declares that she has no competing interests.

Attending Radiologist

Assistant Professor of Radiology

Memorial Sloan-Kettering Cancer Center

New York

NY

利益声明

SM declares that she has no competing interests.

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