最近审阅: 29 十月 2020
最近更新: 19 十月 2018

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 面部充血
  • 锁骨上脂肪垫
  • 紫纹
  • 未妊娠
  • 月经不调
  • 无营养不良
  • 无酗酒
  • 无生理压力
  • 儿童线性生长减速

其他诊断因素

  • 女性
  • 高血压
  • 糖耐量异常和糖尿病
  • 过早的骨质疏松和原因不明的骨折
  • 体重增加和向心性肥胖
  • 痤疮
  • 精神症状
  • 性欲减退
  • 易瘀伤
  • 虚弱
  • 满月脸
  • 颈背部脂肪垫
  • 原因不明的肾结石
  • 多毛症

危险因素

  • 外源性皮质类固醇的使用
  • 垂体腺瘤
  • 肾上腺腺瘤
  • 肾上腺癌
  • 神经内分泌肿瘤
  • 胸腺癌或支气管癌

诊断性检查

首要检查

  • 尿妊娠试验
  • 血清葡萄糖
  • 深夜唾液皮质醇
  • 1 mg 过夜地塞米松抑制试验
  • 24 小时尿游离皮质醇
  • 48 小时 2 mg(小剂量),口服地塞米松抑制试验
更多 首要检查

需考虑的检查

  • 血浆硫酸脱氢表雄酮(DHEAS)水平
  • 清晨血浆促肾上腺皮质激素 (ACTH) 水平
  • 大剂量地塞米松抑制试验
  • 垂体 MRI 检查
  • 肾上腺 CT
  • 岩下窦采样
  • 胸部、腹部和盆腔 CT
  • 胸部 MRI
  • PET 扫描
  • 奥曲肽扫描
更多 需考虑的检查

治疗流程

撰稿人

Professor of Medicine (Endocrinology) and Neurological Surgery

Director

Pituitary Center

Oregon Health & Science University

Portland

OR

利益声明

MF is the Pituitary Society's President Elect, and sits on it's Board of Directors. She holds a research grant to the University for Clinical Studies as Principal Investigator for Novartis and Strongbridge, and is Scientific Consultant for Novartis and Strongbridge. MF is an author of several references cited in this monograph.

Dr Maria Fleseriu would like to gratefully acknowledge Dr Ty Carroll and Dr James Finding, previous contributors to this monograph. TC is an author of a number of references cited in this monograph. He is an investigator in clinical trials sponsored by Corcept. JF is an author of a number of references cited in this monograph. He is a consultant for, and investigator in, clinical trials sponsored by Corcept and Novartis.

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Professor of Medicine

Director of Research

College of Medical and Dental Sciences

University of Birmingham

Honorary Consultant Physician

Queen Elizabeth Hospital

Birmingham

UK

利益声明

PMS declares that he has no competing interests.

Head

Department of Endocrinology

University Hospital of Bordeaux

Pessac

France

利益声明

AT declares that he has no competing interests.

Chief

Endocrine Research Department

Instituto de Investigaciones Médicas A. Lanari

University of Buenos Aires and IDIM-CONICET

Buenos Aires

Argentina

利益声明

LC declares that she has no competing interests.

Professor of Medicine

Director

Division of Endocrinology, Diabetes & Metabolism

University of Texas Medical School

Houston

TX

利益声明

PRO declares that he has no competing interests.

Assistant Professor

Department of Endocrine Neoplasia and Hormonal Disorders

Division of Internal Medicine

University of Texas MD Anderson Cancer Center

Houston

TX

利益声明

MAH declares that he has no competing interests.

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