最后审阅: 20 九月 2021
最后更新: 26 八月 2021

小结

定义

病史和体格检查

关键诊断因素

  • 贫血
  • 骨痛
  • 未定性的单克隆丙种球蛋白病 (MGUS)

危险因素

  • 未定性的单克隆丙种球蛋白病 (MGUS)
  • 异常游离轻链比
  • MM 的家族史
  • 放射暴露
  • 石油产品暴露

诊断性检查

首要检查

  • 血清/尿电泳
  • 全身低剂量 CT(WBLD-CT)
  • 骨骼检查
  • 血清游离轻链测定
  • 骨髓穿刺和活检
  • 血清钙
  • 全血细胞计数 (FBC)
  • 肌酐、尿素
  • 血清 β2 微球蛋白
  • 血清白蛋白

需考虑的检查

  • 全身 MRI
  • 18 氟-氟代脱氧葡萄糖正电子发射断层扫描 (FDG-PET)/FDG-PET-CT
  • C 反应蛋白 (CRP)
  • LDH
  • 细胞遗传学和荧光原位杂交分析

治疗流程

撰稿人

作者

Loredana Santo, MD

Research Fellow

Massachusetts General Hospital

Harvard Medical School

Boston

MA

利益声明

LS is an author of one reference cited in this topic.

Matthew M. Lei, PharmD

Clinical Pharmacist Medical Oncology

Massachusetts General Hospital

Boston

MA

利益声明

MML has consulted for Heron Therapeutics, Fresenius Kabi USA, and Intervention Insights and has received honoraria from AbbVie and Epizyme. MML is an author of some references cited in this topic.

Noopur Raje, MD
Noopur Raje

Director of Multiple Myeloma Program

Massachusetts General Hospital

Harvard Medical School

Boston

MA

利益声明

NR has consulted for Celgene, Takeda, Amgen, Bristol Myers Squibb, Janssen Pharmaceutica, Karyopharm Therapeutics, Bluebird Bio, and Novartis. She has received research funds from Eli Lilly and AstraZeneca. NR is an author of several references cited in this topic.

鸣谢

Dr Loredana Santo, Dr Matthew M. Lei, and Dr Noopur Raje would like to gratefully acknowledge Dr Sonia Vallet, a previous contributor to this topic.

利益声明

SV declares that she has no competing interests.

同行评议者

Shaji Kumar, MD

Associate Professor of Medicine

Mayo Clinic

Rochester

MN

利益声明

SK declares that he has no competing interests.

Faith Davies, MD

Institute of Cancer Research

Sutton

Surrey

UK

利益声明

FD declares that she has no competing interests.

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