小结
定义
病史和体格检查
关键诊断因素
- 存在的危险因素
- 疲劳
- 干眼
- 口干
其他诊断因素
- 血管炎
- 龋齿
- 口部真菌和细菌感染几率增加
- 关节痛
- 肌痛
- 关节炎
- 肾病
- 周围神经病
- 角膜溃疡
- 唾液池消失
- 唾液腺肿大
- 面部疼痛
- 灼口综合征
- 静脉血栓栓塞史
- 主动脉瘤或主动脉夹层病史
危险因素
- 女性
- 系统性红斑狼疮 (SLE)
- 类风湿关节炎
- 系统性硬化症（硬皮病）
- II 类 HLA 标志物
- 基因遗传学
- 高发年龄段是 20~30 岁左右以及绝经后
诊断性检查
首要检查
- Schirmer试验
- 抗 60 kD (SS-A) Ro 和抗 La (SS-B)抗体
需考虑的检查
- 唾液流量测定
- 小唾液腺活检
- 丽丝胺绿测试
- 荧光素角膜染色检查
- 腮腺导管造影
- 唾液腺锝-99m 高锝酸盐闪烁显像
- 皮肤活检
- 血管造影术
- 尿液分析
- 血清电解质
新兴检查
- 唾液腺 MRI
- 唾液腺超声
治疗流程
干眼
口干
伴乏力
伴肌肉骨骼症状
伴血管炎
伴肾小管性酸中毒
伴有神经病
撰稿人
作者
Biji T. Kurien, PhD
Professor of Research
Section of Endocrinology and Diabetes
Department of Medicine
University of Oklahoma Health Sciences Center
Affiliate
Arthritis and Clinical Immunology Research Program
Oklahoma Medical Research Foundation
Research Associate
Department of Veterans Affairs
Oklahoma City
OK
利益声明
BTK is an author of several articles cited in this topic.
R. Hal Scofield, MD
Professor and Director of Fellowship Program
Section of Endocrinology and Diabetes
Department of Medicine
University of Oklahoma Health Sciences Center
Member of Arthritis and Clinical Immunology Research Program
Oklahoma Medical Research Foundation
Associate Chief of Staff for Research
Department of Veterans Affairs
Oklahoma City
OK
利益声明
RHS received honorarium and travel expenses from Eisai Korea for speaking at the Korean Rheumatology Association meeting. RHS has been a paid consultant for UCB in regards to Sjogren's and he has received honorarium for speaking on Sjogren's at Lily. Both instances included travel expenses. RHS is an author of several articles cited in this topic.
同行评议者
Maureen Rischmueller, MD
Head of Unit
Queen Elizabeth Hospital
Woodville South
South Australia
Australia
利益声明
MR declares that she has no competing interests.
Alan Baer, MD
Associate Professor of Medicine
Johns Hopkins University
Baltimore
MD
利益声明
AB declares that he has no competing interests.
鉴别诊断
- 系统性红斑狼疮 (SLE)
- 类风湿关节炎
- 丙型肝炎
更多 鉴别诊断指南
- 2017 年干燥综合征临床实践指南
- 英国风湿病学会原发性干燥综合征成人患者管理指南
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