小结
定义
病史和体格检查
关键诊断因素
- 疲劳
- 干眼
- 口干
其他诊断因素
- 血管炎
- 龋齿
- 存在的危险因素
- 口部真菌和细菌感染几率增加
- 肌肉骨骼疼痛
- 甲状腺疾病
- 泌尿生殖系统疾病
- 肺部疾病
- 胃肠道疾病
- 周围神经病
- 角膜溃疡
- 唾液池消失
- 唾液腺肿大
- 面部疼痛
- 灼口综合征
危险因素
- 女性
- 系统性红斑狼疮 (SLE)
- 类风湿关节炎
- 系统性硬化症（硬皮病）
- II 类 HLA 标志物
- 40-70 岁
- 基因遗传学
诊断性检查
首要检查
- Schirmer试验
- 抗 60 kD (SS-A) Ro 和抗 La (SS-B)抗体
需考虑的检查
- 唾液流量测定
- 小唾液腺活检
- 丽丝胺绿测试
- 荧光素角膜染色检查
- 腮腺导管造影
- 唾液腺锝-99m 高锝酸盐闪烁显像
- 皮肤活检
- 血管造影术
- 尿液分析
- 血清电解质
新兴检查
- 唾液腺 MRI
- 唾液腺超声
治疗流程
干眼
口干
伴乏力
伴有肌肉骨骼表现
伴血管炎
伴肾小管性酸中毒
伴有神经病
撰稿人
作者
Biji T. Kurien, PhD
Staff Scientist
Arthritis and Clinical Immunology Research Program
Oklahoma Medical Research Foundation
Research Associate
Department of Veterans Affairs
Oklahoma City
OK
利益声明
BTK is an author of several articles cited in this topic.
R. Hal Scofield, MD
Professor
Section of Endocrinology and Diabetes
Department of Medicine
University of Oklahoma Health Sciences Center
Member
Arthritis and Clinical Immunology Research Program
Oklahoma Medical Research Foundation
Associate Chief of Staff for Research and Staff Physician
Department of Veterans Affairs Medical Center
Oklahoma City
OK
利益声明
RHS received honorarium and travel expenses from Eisai Korea for speaking at the Korean Rheumatology Association meeting. RHS has been a paid consultant for UCB in regards to Sjogren's and he has received honorarium for speaking on Sjogren's at Lily. Both instances included travel expenses. RHS is an author of several articles cited in this topic.
同行评议者
Nora Sandorfi, MD
Associate Professor of Medicine
University of Pennsylvania
Philadelphia
PA
利益声明
NS declares she has no competing interests.
鉴别诊断
- 系统性红斑狼疮 (SLE)
- 类风湿关节炎
- 丙型肝炎
更多 鉴别诊断指南
- 风湿性和肌肉骨骼疾病患者的疫苗接种指南
- 干燥综合征患者肺部疾病评估和管理共识指南
更多 指南
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