最近审阅: 26 十月 2020
最近更新: 19 十一月 2019

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 疲劳
  • 干眼
  • 口干

其他诊断因素

  • 血管炎
  • 龋齿
  • 口部真菌和细菌感染几率增加
  • 关节痛
  • 肌痛
  • 关节炎
  • 肾病
  • 周围神经病
  • 角膜溃疡
  • 唾液池消失
  • 唾液腺肿大
  • 面部疼痛
  • 灼口综合征
  • 静脉血栓栓塞史
  • 主动脉瘤或主动脉夹层病史

危险因素

  • 女性
  • 系统性红斑狼疮 (SLE)
  • 类风湿关节炎
  • 系统性硬化症(硬皮病)
  • II 类 HLA 标志物
  • 基因遗传学
  • 高发年龄段是 20~30 岁左右以及绝经后

诊断性检查

首要检查

  • Schirmer试验
  • 抗 60 kD (SS-A) Ro 和抗 La (SS-B)抗体
更多 首要检查

需考虑的检查

  • 唾液流量测定
  • 小唾液腺活检
  • 丽丝胺绿测试
  • 荧光素角膜染色检查
  • 腮腺导管造影
  • 唾液腺锝-99m 高锝酸盐闪烁显像
  • 皮肤活检
  • 血管造影术
  • 尿液分析
  • 血清电解质
更多 需考虑的检查

新兴检查

  • 唾液腺 MRI
  • 唾液腺超声
更多 新兴检查

治疗流程

撰稿人

Professor of Research

Section of Endocrinology and Diabetes

Department of Medicine

University of Oklahoma Health Sciences Center

Affiliate

Arthritis and Clinical Immunology Research Program

Oklahoma Medical Research Foundation

Research Associate

Department of Veterans Affairs

Oklahoma City

OK

利益声明

BTK is an author of several articles cited in this topic.

Professor and Director of Fellowship Program

Section of Endocrinology and Diabetes

Department of Medicine

University of Oklahoma Health Sciences Center

Member of Arthritis and Clinical Immunology Research Program

Oklahoma Medical Research Foundation

Associate Chief of Staff for Research

Department of Veterans Affairs

Oklahoma City

OK

利益声明

RHS received honorarium and travel expenses from Eisai Korea for speaking at the Korean Rheumatology Association meeting. RHS has been a paid consultant for UCB in regards to Sjogren's and he has received honorarium for speaking on Sjogren's at Lily. Both instances included travel expenses. RHS is an author of several articles cited in this topic.

同行评议者展开全部内容

Head of Unit

Queen Elizabeth Hospital

Woodville South

South Australia

Australia

利益声明

MR declares that she has no competing interests.

Associate Professor of Medicine

Johns Hopkins University

Baltimore

MD

利益声明

AB declares that he has no competing interests.

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