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干燥综合征

最后审阅: 6 Oct 2024
最后更新: 27 Jul 2023

小结

定义

病史和体格检查

关键诊断因素

  • 疲劳
  • 干眼
  • 口干
完整详情

其他诊断因素

  • 血管炎
  • 龋齿
  • 存在的危险因素
  • 口部真菌和细菌感染几率增加
  • 肌肉骨骼疼痛
  • 甲状腺疾病
  • 泌尿生殖系统疾病
  • 肺部疾病
  • 胃肠道疾病
  • 周围神经病
  • 角膜溃疡
  • 唾液池消失
  • 唾液腺肿大
  • 面部疼痛
  • 灼口综合征
完整详情

危险因素

  • 女性
  • 系统性红斑狼疮 (SLE)
  • 类风湿关节炎
  • 系统性硬化症(硬皮病)
  • II 类 HLA 标志物
  • 40-70 岁
  • 基因遗传学
完整详情

诊断性检查

首要检查

  • Schirmer试验
  • 抗 60 kD (SS-A) Ro 和抗 La (SS-B)抗体
完整详情

需考虑的检查

  • 唾液流量测定
  • 小唾液腺活检
  • 丽丝胺绿测试
  • 荧光素角膜染色检查
  • 腮腺导管造影
  • 唾液腺锝-99m 高锝酸盐闪烁显像
  • 皮肤活检
  • 血管造影术
  • 尿液分析
  • 血清电解质
完整详情

新兴检查

  • 唾液腺 MRI
  • 唾液腺超声

治疗流程

持续性治疗

干眼

口干

伴乏力

伴有肌肉骨骼表现

伴血管炎

伴肾小管性酸中毒

伴有神经病

撰稿人

作者

Biji T. Kurien, PhD

Staff Scientist

Arthritis and Clinical Immunology Research Program

Oklahoma Medical Research Foundation

Research Associate

Department of Veterans Affairs

Oklahoma City

OK

利益声明

BTK is an author of several articles cited in this topic.

R. Hal Scofield, MD

Professor

Section of Endocrinology and Diabetes

Department of Medicine

University of Oklahoma Health Sciences Center

Member

Arthritis and Clinical Immunology Research Program

Oklahoma Medical Research Foundation

Associate Chief of Staff for Research and Staff Physician

Department of Veterans Affairs Medical Center

Oklahoma City

OK

利益声明

RHS received honorarium and travel expenses from Eisai Korea for speaking at the Korean Rheumatology Association meeting. RHS has been a paid consultant for UCB in regards to Sjogren's and he has received honorarium for speaking on Sjogren's at Lily. Both instances included travel expenses. RHS is an author of several articles cited in this topic.

同行评议者

Nora Sandorfi, MD

Associate Professor of Medicine

University of Pennsylvania

Philadelphia

PA

利益声明

NS declares she has no competing interests.

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