干燥综合征

以泪腺和唾液腺分泌减少（复合干燥征）为特征的慢性炎症和自身免疫紊乱。

可表现为疲乏、眼干（干燥性角结膜炎）和口干（口腔干燥）。

根据抗核抗体、抗 60 kD（SS-A）Ro 和抗 La 自身抗体阳性，唾液和泪液产生减少，唇腺活检显示淋巴细胞浸润进行诊断。

以对症治疗为主。

干燥综合征是一种系统性自身免疫性疾病[1]Nocturne G, Mariette X. Advances in understanding the pathogenesis of primary Sjogren's syndrome. Nat Rev Rheumatol. 2013 Sep;9(9):544-56. http://www.ncbi.nlm.nih.gov/pubmed/23857130?tool=bestpractice.com 其特征是淋巴细胞浸润泪腺和唾液腺导致的眼干（角结膜干燥症）和口干（口干燥症）。其他症状可包括皮肤、鼻腔、咽喉、阴道干燥；关节痛和肌痛；周围神经病变；肺、甲状腺和肾脏疾病；以及淋巴瘤。[2]Fox PC. Autoimmune diseases and Sjogren's syndrome, an autoimmune exocrinopathy. Ann N Y Acad Sci. 2007 Mar;1098:15-21. http://www.ncbi.nlm.nih.gov/pubmed/17332090?tool=bestpractice.com 干燥综合征可单独发生（原发性干燥综合征）；或伴其他自身免疫性疾病发生（继发性干燥综合征），例如狼疮、类风湿性关节炎和系统性硬化症。[3]Anaya JM, Tobon GJ, Vega P, et al. Autoimmune disease aggregation in families with primary Sjogren's syndrome. J Rheumatol. 2006 Nov;33(11):2227-34. http://www.ncbi.nlm.nih.gov/pubmed/17086607?tool=bestpractice.com [4]Steinberg AD, Talal N. The coexistence of Sjogren's syndrome and systemic lupus erythematosus. Ann Intern Med. 1971 Jan;74(1):55-61. http://www.ncbi.nlm.nih.gov/pubmed/5312811?tool=bestpractice.com [5]Moutsopoulos HM, Webber BL, Vlagopoulos TP, et al. Differences in the clinical manifestations of sicca syndrome in the presence and absence of rheumatoid arthritis. Am J Med. 1979 May;66(5):733-6. http://www.ncbi.nlm.nih.gov/pubmed/443249?tool=bestpractice.com [6]Foster H, Fay A, Kelly C, et al. Thyroid disease and other autoimmune phenomena in a family study of primary Sjogren's syndrome. Br J Rheumatol. 1993 Jan;32(1):36-40. http://www.ncbi.nlm.nih.gov/pubmed/8422556?tool=bestpractice.com [7]Alarcon-Segovia D, Ibanez G, Hernandez-Ortiz J, et al. Sjogren's syndrome in progressive systemic sclerosis (scleroderma). Am J Med. 1974 Jul;57(1):78-85. http://www.ncbi.nlm.nih.gov/pubmed/4134767?tool=bestpractice.com