最近审阅: 1 十一月 2020
最近更新: 15 十月 2019

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 一级亲属早发型冠心病或血脂异常的家族史
  • 心血管疾病史
  • 饱和脂肪和反式脂肪酸的摄入量
  • 超重(尤其是腹型肥胖)
  • 黄斑瘤
  • 腱性黄色瘤

其他诊断因素

  • 45 岁前发生角膜弓
  • 结节性黄色瘤

危险因素

  • 胰岛素抵抗和2型糖尿病
  • 超重(体重指数>25 kg/m²)
  • 吸烟
  • 甲状腺功能减退
  • 胆汁淤积性肝病
  • 肾病综合征
  • 与用药的关系

诊断性检查

首要检查

  • 血脂检查
  • 血清促甲状腺激素 (TSH)
  • 脂蛋白(a)
更多 首要检查

治疗流程

撰稿人

Raul D. Santos

Associate Professor of Medicine

Director Lipid Clinic Heart Institute (InCor)

University of Sao Paulo Medical School Hospital

Scientific Advisor

Hospital Israelita Albert Einstein

Sao Paulo

Brazil

利益声明

RDS has received honoraria for consulting, speaker activities and research from Astra Zeneca, Amgen, Akcea, Biolab, Esperion, Kowa, Pfizer, Merck, Novo-Nordisk, and Sanofi/Regeneron.

Seth S. Martin

Associate Professor of Medicine/Cardiology

Director

Lipid Clinic

Ciccarone Center for the Prevention of Cardiovascular Disease

Division of Cardiology, Department of Medicine

Johns Hopkins University School of Medicine

Baltimore

MD

利益声明

SSM has received honoraria from the American College of Cardiology for educational activities. SSM is listed as a co-inventor on a pending patent filed by Johns Hopkins University for a novel method of LDL-cholesterol estimation. SSM received a charitable gift for the VLDL big data project from the David and June Trone Family Foundation, and has also received research support from the PJ Schafer Cardiovascular Research Fund, American Heart Association, Aetna Foundation, iHealth, Stanford MedX/Nokia, Google, and Apple. SSM has acted as a consultant for Abbott Nutrition, Pressed Juicery, Quest Diagnostics, Sanofi/Regeneron, Amgen, Novo Nordisk, Esperian, Akcea, and the Pew Institute.

Rhanderson Cardoso

Cardiovascular Fellow

Pollin Prevention Fellow

Ciccarone Center for the Prevention of Cardiovascular Disease

Division of Cardiology, Department of Medicine

Johns Hopkins University School of Medicine

Baltimore

MD

利益声明

RC declares that he has no competing interests.

Dr Raul D. Santos, Dr Seth S. Martin, and Dr Rhanderson Cardoso would like to gratefully acknowledge Dr Martin Engelhardt and Dr Michael Miller, the previous contributors to this topic.

利益声明

ME declares that he has no competing interests. MM has received research grant support and honoraria for lectures from AstraZeneca, Merck-Schering Plough, and Pfizer. MM has received consulting fees from Pfizer, Merck-Schering Plough, and Roche.

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Assistant Professor of Medicine

Noninvasive Cardiology

MetroHealth Campus

Case Western Reserve University

Cleveland

OH

利益声明

MLA declares that he has no competing interests.

Consultant/Senior Lecturer in Diabetes & Metabolism

The Royal Oldham Hospital & University of Manchester Cardiovascular Research Group Diabetes Centre

Royal Oldham Hospital

Oldham

UK

利益声明

DB declares that he has no competing interests.

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