发病率随着超重或肥胖的人群数量增加而增加。
伴随心血管疾病危险增加。
空腹甘油三酯水平>5.7mmol/L(500mg/dL)时，可能引起急性胰腺炎。
所有患者的治疗中均应包括生活方式调整。
如果患者同时存在≥2个心血管危险因素，且甘油三酯<5.69mmol/L(<500mg/dL)，他汀类药物为首选治疗。
对于甘油三酯≥5.69 mmol/L (≥500 mg/dL) 的患者，使用贝丁酸衍化物或鱼油作为一线治疗。对于甘油三酯＜5.69 mmol/L (<500 mg/dL) 的患者，可在他汀类药物基础上加用此类药物，以实现治疗目标。
美国国家胆固醇教育计划成人治疗专家组的第三次指南将高甘油三酯血症定义为空腹血浆甘油三酯水平≥2.3 mmol/L (≥200 mg/dL)。临界性高甘油三酯血症的定义为 150-199 mg/dL，高甘油三酯血症为 200-499 mg/dL，极高甘油三酯血症为≥500 mg/dL。[1]Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) - executive summary. JAMA. 2001 May 16;285(19):2486-97.
http://www.ncbi.nlm.nih.gov/pubmed/11368702?tool=bestpractice.com
[2]Kushner PA, Cobble ME. Hypertriglyceridemia: the importance of identifying patients at risk. Postgrad Med. 2016 Nov;128(8):848-58.
http://www.ncbi.nlm.nih.gov/pubmed/27710158?tool=bestpractice.com
当甘油三酯水平≥11.3 mmol/L (≥1000 mg/dL) 时，会出现乳糜微粒血症。一些国家/地区和国际医疗组织关于高甘油三酯血症的确定和治疗的指南使用不同的术语，但他们的建议是相似的。[3]Jellinger PS, Handelsman Y, Rosenblit PD, et al. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia and prevention of cardiovascular disease. Endocr Pract. 2017 Apr;23(Suppl 2):1-87.
http://journals.aace.com/doi/pdf/10.4158/EP171764.APPGL
http://www.ncbi.nlm.nih.gov/pubmed/28437620?tool=bestpractice.com
[4]Anderson TJ, Grégoire J, Pearson GJ, et al. 2016 Canadian Cardiovascular Society guidelines for the management of dyslipidemia for the prevention of cardiovascular disease in the adult. Can J Cardiol. 2016 Nov;32(11):1263-82.
https://www.onlinecjc.ca/article/S0828-282X(16)30732-2/pdf
http://www.ncbi.nlm.nih.gov/pubmed/27712954?tool=bestpractice.com
[5]Hegele RA, Ginsberg HN, Chapman MJ, et al.; European Atherosclerosis Society Consensus Panel. The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol. 2014 Aug;2(8):655-66.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201123/
http://www.ncbi.nlm.nih.gov/pubmed/24731657?tool=bestpractice.com
