小结
定义
意义未明的单克隆免疫球蛋白血症 (monoclonal gammopathy of undetermined significance, MGUS) 是一种无症状疾病，与发生多发性骨髓瘤和相关浆细胞增殖性恶性肿瘤的风险增加相关。该病的诊断必须满足下列标准：血清或尿液中存在单克隆 (monoclonal, M) 蛋白（血清浓度＜30 g/L [3 g/dL] 或尿液浓度＜500 mg/24 小时）；骨髓中浆细胞＜10%（只有在 M 蛋白＞15 g/L [1.5 g/dL]、存在非 IgG 型 MGUS 或游离轻链比例异常时，才需要骨髓检查）；且无溶骨性病变、贫血、高钙血症、肾功能不全或与浆细胞增殖过程有关的淀粉样变性。[1]
[Figure caption and citation for the preceding image starts]: 骨髓活检加苏木精-伊红染色显示浆细胞轻度增加。（图片）由 Ola Landgren, MD, PhD 提供 [Citation ends].
[Figure caption and citation for the preceding image starts]: CD138 免疫组化染色突显出小群浆细胞。（图片）由 Ola Landgren, MD, PhD 提供 [Citation ends].
病史和体格检查
诊断性检查
治疗流程
撰稿人
作者
Professor of Medicine
Division of Hematology
Mayo Clinic
Rochester
MN
利益声明
SK has served as a consultant for Janssen, Abbvie, Amgen, Merck, Celgene, Takeda, and Skyline.
Professor Shaji Kumar would like to gratefully acknowledge Dr Ola Landgren, a previous contributor to this topic. OL is an author of several references cited in this topic.
同行评议者
Consultant Haemato-Oncologist
Section of Haemato-Oncology
Brookes Lawley Institute of Cancer
Sutton
UK
利益声明
DC declares that he has no competing interests.
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