小结
定义
病史和体格检查
关键诊断因素
- 儿童痫样发作家族史
- 凝视发作,持续 5 至 10 秒;每天数次,无先兆/发作后状态
- 儿童期发病
- 体格检查结果正常
- 过度通气诱导的癫痫发作
其他诊断因素
- 简单自动症
- 近期学习成绩下降
- 复杂自动症
- 早发型(4 岁之前)
危险因素
- 儿童失神癫痫或青少年肌阵挛癫痫家族史/遗传史
- 获得性脑损伤:例如缺氧-缺血、外伤、感染
- 其他先天性代谢障碍、结构性缺陷、染色体异常
- 发育迟缓或精神发育迟滞
- 女性
诊断性检查
首要检查
- 脑电图 (EEG)
需考虑的检查
- 颅脑 MRI 扫描
- 代谢性疾病检测(例如血清氨基酸、尿有机酸、乳酸/丙酮酸或特定酶试验)
- 脑脊液和血清中的葡萄糖
新兴检查
- 基因检测
治疗流程
无全身性强直阵挛发作病史(儿童失神癫痫)的典型失神发作
有全身性强直阵挛发作病史(CAE、JAE、JME)的典型失神发作
非典型失神发作
顽固性疾病的治疗
撰稿人
作者
Judith L. Z. Weisenberg, MD
Assistant Professor of Neurology
Washington University Medical School
St. Louis
MO
利益声明
JLZW receives 2% salary support from Marinus Pharmaceuticals as site PI for the Marigold Study; 2% salary support from the International Foundation of CDKL5 Research; and 1% salary support as site sub-PHI for the Rett Syndrome Natural History Study. These are all paid to Washington University in St. Louis. JLZW declares that these have no direct relationship to this topic.
鸣谢
Dr Judith L. Z. Weisenberg would like to gratefully acknowledge Dr Michael Wong, a previous contributor to this topic. MW declares that he has no competing interests.
同行评议者
Anita Devlin, MBBS, MD
Consultant Paediatric Neurologist
Royal Victoria Infirmary
NHS Foundation Trust
Newcastle-upon-Tyne
UK
利益声明
AD and two epilepsy nurses from her department have been reimbursed by UCB Pharma, the manufacturer of levetiracetum, for attending several conferences. One of the epilepsy nurses received a one-off sponsorship payment from UCB Pharma to cover the initial set-up costs of the adolescent epilepsy support group. One epilepsy nurse has been reimbursed by Cyberonics, the manufacturer of vagal nerve stimulators, for attending one or more conferences.
Cigdem Akman, MD
Division of Pediatric Neurology
Columbia University College of Physicians and Surgeons
New York
NY
利益声明
CA declares that he has no competing interests.
Angus A. Wilfong, MD
Associate Professor
Pediatrics and Neurology
Baylor College of Medicine
Medical Director
Comprehensive Epilepsy Program
Texas Children's Hospital
Houston
TX
利益声明
AAW declares that he has no competing interests.
Helen Cross, MB, ChB, PhD, FRCP, FRCPCH
Head of Neurosciences Unit
The Prince of Wales’s Chair of Childhood Epilepsy
National Centre for Young People with Epilepsy
London
UK
利益声明
HC has received research funds from HAS, Epilepsy Research UK, SHS, and the Milk Development Council. She has received funding for an epilepsy training fellowship from UCB and Eisai. She has also received travel funding from Eisai, UCB, and GlaxoSmithKline.
鉴别诊断
- 白日梦
- 注意缺陷多动障碍 (ADHD)
- 起源于额叶或颞叶的复杂部分性癫痫
更多 鉴别诊断指南
- 癫痫:诊断和治疗
- 实践指南更新总结:新型抗癫痫药的有效性和耐受性 II:难治性癫痫
更多 指南患者教育信息
Absence seizures in children
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