小结
定义
病史和体格检查
关键诊断因素
- 存在的危险因素
- 口腔黏膜红斑或溃疡
- 口腔疼痛
其他诊断因素
- 饮食受限
- 腹泻
- 发热
危险因素
- 强化化疗方案
- 口腔的放疗
- 放化疗
- 药物代谢酶的基因多态性
诊断性检查
首要检查
- 临床诊断
需考虑的检查
- 全血细胞计数 (FBC) 和分类计数
- 血液培养
- 病损表面真菌涂片显微镜检
- 真菌培养
- 病毒培养和聚合酶链反应（PCR）
治疗流程
进行造血干细胞移植：预防措施
静脉推注氟尿嘧啶：预防措施
接受口腔放疗：预防措施
已确诊口腔黏膜炎
撰稿人
作者
Rajesh V. Lalla, DDS, PhD, DABOM
Associate Professor
Associate Dean for Research
Section of Oral Medicine
University of Connecticut School of Dental Medicine
Farmington
CT
利益声明
RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics and Novartis.
Ourania Nicolatou-Galitis, DDS, MSc, DrDent
Professor
Hospital Dentistry
National & Kapodistrian University of Athens
Athens
Greece
利益声明
ONG has received fees from Angelini pharma to author a review article on oral mucositis. ONG is an author of several references cited in this topic.
Nikolaos Tsoukalas, MD, MSc, PhD
Medical Oncologist
Associate Director
Department of Oncology
401 General Military Hospital
Athens
Greece
利益声明
NT declares that he has no competing interests.
鸣谢
Professor Ourania Nicolatou-Galitis and Dr Nikolaos Tsoukalas would like to gratefully acknowledge Dr Eleni Arvanitou, who contributed to the updating of this topic, and Dr Rajesh V. Lalla, a previous contributor.
利益声明
EA declares that she has no competing interests. RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics, and Novartis.
同行评议者
Michael Brennan, DDS, MHS
Associate Chairman and Oral Medicine Residency Director
Department of Oral Medicine
Carolinas Medical Center
Charlotte
NC
利益声明
MB is an author of a reference cited in this topic. MB is part of the Mucositis Study Group of MASCC/ISOO, and participated in the review of mucositis.
Maria Michelagnoli, MB ChB, MD, FRCPCH
Consultant Pediatric and Adolescent Oncologist
University College London Hospitals
London
UK
利益声明
MM declares that she has no competing interests.
鉴别诊断
- 口腔念珠菌病
- 单纯疱疹病毒感染
- 移植物抗宿主病
更多 鉴别诊断指南
- 在接受癌症治疗或接受造血干细胞移植的儿童中预防口腔和口咽黏膜炎的指南
- MASCC/ISOO关于继发于恶性肿瘤治疗的黏膜炎的临床实践指南
更多 指南
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