口腔黏膜炎

最后审阅: 4 六月 2022
最后更新: 12 八月 2021

小结

定义

病史和体格检查

关键诊断因素

  • 存在的危险因素
  • 口腔黏膜红斑或溃疡
  • 口腔疼痛
更多 关键诊断因素

其他诊断因素

  • 饮食受限
  • 腹泻
  • 发热
其他诊断因素

危险因素

  • 强化化疗方案
  • 口腔的放疗
  • 放化疗
  • 药物代谢酶的基因多态性
更多 危险因素

诊断性检查

首要检查

  • 临床诊断
更多 首要检查

需考虑的检查

  • 全血细胞计数 (FBC) 和分类计数
  • 血液培养
  • 病损表面真菌涂片显微镜检
  • 真菌培养
  • 病毒培养和聚合酶链反应(PCR)
更多 需考虑的检查

治疗流程

初步治疗

进行造血干细胞移植:预防措施

静脉推注氟尿嘧啶:预防措施

接受口腔放疗:预防措施

急症处理

已确诊口腔黏膜炎

撰稿人

作者

Rajesh V. Lalla, DDS, PhD, DABOM

Associate Professor

Associate Dean for Research

Section of Oral Medicine

University of Connecticut School of Dental Medicine

Farmington

CT

利益声明

RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics and Novartis.

Ourania Nicolatou-Galitis, DDS, MSc, DrDent

Professor

Hospital Dentistry

National & Kapodistrian University of Athens

Athens

Greece

利益声明

ONG has received fees from Angelini pharma to author a review article on oral mucositis. ONG is an author of several references cited in this topic.

Nikolaos Tsoukalas, MD, MSc, PhD

Medical Oncologist

Associate Director

Department of Oncology

401 General Military Hospital

Athens

Greece

利益声明

NT declares that he has no competing interests.

鸣谢

Professor Ourania Nicolatou-Galitis and Dr Nikolaos Tsoukalas would like to gratefully acknowledge Dr Eleni Arvanitou, who contributed to the updating of this topic, and Dr Rajesh V. Lalla, a previous contributor.

利益声明

EA declares that she has no competing interests. RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics, and Novartis.

同行评议者

Michael Brennan, DDS, MHS

Associate Chairman and Oral Medicine Residency Director

Department of Oral Medicine

Carolinas Medical Center

Charlotte

NC

利益声明

MB is an author of a reference cited in this topic. MB is part of the Mucositis Study Group of MASCC/ISOO, and participated in the review of mucositis.

Maria Michelagnoli, MB ChB, MD, FRCPCH

Consultant Pediatric and Adolescent Oncologist

University College London Hospitals

London

UK

利益声明

MM declares that she has no competing interests.

  • 口腔黏膜炎 images
  • 鉴别诊断

    • 口腔念珠菌病
    • 单纯疱疹病毒感染
    • 移植物抗宿主病
    更多 鉴别诊断
  • 指南

    • 在接受癌症治疗或接受造血干细胞移植的儿童中预防口腔和口咽黏膜炎的指南
    • MASCC/ISOO关于继发于恶性肿瘤治疗的黏膜炎的临床实践指南
    更多 指南
  • padlock-locked登录或订阅即可浏览 BMJ Best Practice 临床实践完整内容

内容使用需遵循免责声明