最近审阅: 23 十月 2020
最近更新: 28 三月 2018

小结

定义

病史和体格检查

关键诊断因素

  • 排痰性咳嗽
  • 劳累时呼吸急促
  • 当前吸烟者
  • 瓦斯、烟雾以及/或尘土的暴露
  • 肝肿大
  • 腹水
  • 意识模糊

其他诊断因素

  • 32-41岁年龄
  • 男性
  • 哮鸣音
  • 胸部充气过度
  • 巩膜黄疸/黄疸
  • 扑翼样震颤

危险因素

  • AAT 缺乏症家族史

诊断性检查

首要检查

  • 血浆AAT水平
  • 肺功能测试
  • 胸部 X 线检查
  • 胸部 CT
  • 肝功能检查 (LFT)
更多 首要检查

需考虑的检查

  • 表型分型
  • 基因分型
  • 运动试验及动脉血气分析
  • 甲胎蛋白
  • 腹部 CT
更多 需考虑的检查

治疗流程

进行中

撰稿人

D. Kyle Hogarth

Associate Professor

Pulmonary and Critical Care

University of Chicago

Chicago

IL

利益声明

DKH has served as a consultant for CSL Behring: manufacturer of AAT replacement therapy. Has lectured for CSL Behring, Grifols, and Shire: manufacturers of AAT replacement therapy. Research sponsored by Shire: manufacturer of AAT replacement therapy.

Dr D. Kyle Hogarth would like to gratefully acknowledge Dr Paul J. Hutchison, a previous contributor to this monograph. PJH declares that he has no competing interests.

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Assistant Professor of Medicine

David Geffen School of Medicine at UCLA

Los Angeles

CA

利益声明

JD declares that she has no competing interests.

Chair of Quality

Director

Pulmonary Hypertension Clinic

Head

Pulmonary Education and Rehabilitation

Department of Pulmonary, Allergy and Critical Care

Cleveland Clinic Florida

Weston

FL

利益声明

FR has been a consultant and speaker and has received funding from Baxter Healthcare and CSL Behring.

Consultant Chest Physician

Aberdeen Royal Infirmary

Aberdeen

UK

利益声明

GPC declares that he has no competing interests.

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