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Malignant hyperthermia

Last reviewed: 15 Jun 2025
Last updated: 06 Jan 2022

Summary

Definition

病史和体格检查

关键诊断因素

  • presence of risk factors
  • exposure to potent inhalation anaesthetic and/or succinylcholine (suxamethonium)
  • susceptibility to MH
  • previous MH episode
  • positive family history
  • increased minute ventilation
  • elevated core temperature
  • muscle rigidity
完整详情

其他诊断因素

  • tachycardia
  • decreased urine output
  • excessive sweating with exercise
  • muscle cramps
  • spontaneous episodes of severe muscle stiffness
完整详情

危险因素

  • exposure to potent inhalation anaesthetic and/or succinylcholine (suxamethonium)
  • susceptibility to MH
  • previous MH episode
  • positive family history
  • exertional heat illness
完整详情

诊断性检查

首要检查

  • discontinuation of inhalation anaesthetic
  • exhaled carbon dioxide, oxygen consumption (inspired-expired oxygen concentration difference)
  • venous blood gases
  • serum electrolytes
  • serum creatinine
  • therapeutic trial of intravenous dantrolene
  • creatine kinase
  • urinalysis
  • urine myoglobin
  • platelets
  • prothrombin time
完整详情

需考虑的检查

  • caffeine halothane contracture test (CHCT)
  • in vitro contracture test (IVCT)
  • genetic testing
  • screen for muscle enzyme deficiencies
完整详情

治疗流程

急症处理

inhalation anaesthetic-induced

exercise- or heat-induced

撰稿人

作者

Christopher M. Edwards, MD

Assistant Professor

Department of Anesthesiology

University of Florida College of Medicine

Gainesville

FL

利益声明

CME volunteers for the Malignant Hyperthermia Association of the United States (MHAUS), including as a consultant for the malignant hyperthermia hotline. CME is co-author of a chapter on malignant hyperthermia in Fuhrman & Zimmerman’s Pediatric Critical Care, 6th ed., Elsevier.

Nikolaus Gravenstein, MD

Professor

Department of Anesthesiology

University of Florida College of Medicine

Gainesville

FL

利益声明

NG is medical adviser/consultant for LifeFlow (410 Medical) and Teleflex, and has received funding from Merck for delivering education lectures to Merck employees. NG is Medical Director of the North American Malignant Hyperthermia Registry.

鸣谢

Christopher M Edwards and Nikolaus Gravenstein would like to gratefully acknowledge Dr Barbara W. Brandom and Dr Lena Mayes, the previous contributors to this topic.

利益声明

LM declares that she has no competing interests. BWB has been reimbursed by the not-for-profit sponsor of the North American MH Registry (NAMHR), the Malignant Hyperthermia Association of the United States (MHAUS) for attending meetings related to the management of the NAMHR. For the past 16 years, BWB received grants from MHAUS to maintain the NAMHR. BWB was the unpaid director of the NAMHR, until Jul 2016. BWB has given lectures and prepared educational materials for her previous employer, the Department of Anesthesiology in the University of Pittsburgh. As of 1 July, 2016, BWB retired from that employment. BWB has published papers and prepared educational materials for MHAUS, with the help of other volunteers for MHAUS. BWB sponsored LM for an award granted by the American Society of Anesthesiologists. This award allowed LM to travel to several medical centers that were active in the diagnosis of MH, as well as to the NAMHR to improve her understanding of this syndrome. This is part of BWB's mentoring of younger anesthesiologists. BWB is also an author of a number of references cited in this topic.

同行评议者

Henry Rosenberg, MD

Director

Department of Medical Education and Clinical Research

Saint Barnabas Medical Center

Livingstone

NJ

利益声明

HR declares that he has no competing interests.

Philip Hopkins, MD

Professor of Anesthesia

University of Leeds

Academic Unit of Anesthesia

St James's University Hospital

Leeds

UK

利益声明

PH is an author of a number of references cited in this topic.

Thierry Girard, MD

Associate Professor

Perioperative Patient Safety

Department of Biomedicine

University Hospital Basel

Basel

Switzerland

利益声明

TG declares that he has no competing interests.

Joseph Tobin, MD, FAAP, FCCM

Professor and Chairman

Department of Anesthesiology

Wake Forest University School of Medicine

Winston-Salem

NC

利益声明

JT is an author of a number of references cited in this topic.

参考文献

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

关键文献

Hopkins PM, Girard T, Dalay S, et al. Malignant hyperthermia 2020: guideline from the Association of Anaesthetists. Anaesthesia. 2021 May;76(5):655-64.全文  摘要

Larach MG, Dirksen SJ, Belani KG, et al; Society for Ambulatory Anesthesiology; Malignant Hyperthermia Association of the United States; Ambulatory Surgery Foundation; Society for Academic Emergency Medicine; National Association of Emergency Medical Technicians. Special article: Creation of a guide for the transfer of care of the malignant hyperthermia patient from ambulatory surgery centers to receiving hospital facilities. Anesth Analg. 2012;114:94-100.全文  摘要

Larach MG, Localio AR, Allen GC, et al. A clinical grading scale to predict MH susceptibility. Anesthesiology. 1994 Apr;80(4):771-9. 摘要

Hopkins PM, Rüffert H, Snoeck MM, et al. European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility. Br J Anaesth. 2015 Oct;115(4):531-9.全文  摘要

Rüffert H, Bastian B, Bendixen D, et al. Consensus guidelines on perioperative management of malignant hyperthermia suspected or susceptible patients from the European Malignant Hyperthermia Group. Br J Anaesth. 2021 Jan;126(1):120-30.全文  摘要

参考文献

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • 鉴别诊断

    • Non-MH rhabdomyolysis
    • Muscle disuse atrophy
    • Myotonia
    更多 鉴别诊断
  • 指南

    • Malignant hyperthermia 2020
    • Consensus guidelines on perioperative management of malignant hyperthermia suspected or susceptible patients from the European Malignant Hyperthermia Group
    更多 指南
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