Резюме
Определение
Анамнез и осмотр
Ключевые диагностические факторы
- наличие факторов риска
- употребление в пищу молока, яиц, орехов, рыбы, моллюсков, пшеницы или сои
- повторяющиеся симптомы
- покраснение, крапивница и ангиоэдема кожи
- чихание, риноррея или заложенность носа
- одышка, тахипноэ, дистанционные хрипы, кашель или цианоз
- охриплость, стридор или чувство удушья
- тошнота и рвота
- спазмы в животе или вздутие
- диарея
- инъекция конъюнктив или слезотечение
- периорбитальный отек
- внезапное начало симптомов
- реакция, вызванная небольшим количеством пищи
- наличие других аллергических заболеваний
- отек гортани
Другие диагностические факторы
- тахикардия или брадикардия
- реакция усугубляется упражнениями или физическими нагрузками
- употребление алкоголя или лекарственных средств перед реакцией
- сердечные аритмии
- гипотензия
Факторы риска
- пищевая аллергия в семейном анамнезе
- атопический дерматит
- новорожденные
- перинатальный контакт с арахисовым маслом
Диагностические исследования
Исследования, которые показаны в первую очередь
- специфический иммунологический анализ IgE in vitro
- скарификационная проба на коже
Исследования, проведение которых нужно рассмотреть
- пищевые провокационные пробы
- разложенные на составные части диагностикумы
Алгоритм лечения
Составители
Авторы
A. Wesley Burks, MD
Curnen Distinguished Professor and Chair
Department of Pediatrics
University of North Carolina
Chapel Hill
NC
Раскрытие информации
AWB receives grant support to his institution from the National Institutes of Health, Food Allergy Research & Education, and Allergen Research Corporation; royalties from UpToDate; consulting honorariums from Aravax, Astella Pharma Global Development, DBV Technologies and N-Fold, LLC, as well as Aimmune Therapeutics, Consortia TX, Inc., Intrommune Therapeutics, and Prota Therapeutics for his service on their respective Scientific Advisory Boards. AWB has consulted for the following companies (which are all now expired): Biomerica, Inc., Evelo Biosciences/Epiva, Genentech, Insys Therapeutics, PPD Development, Sanofi US Services, Valeant Pharmaceuticals North America, LLC, LEK Consulting, LLC, Hycor Biomedical. AWB has received payments for speaking at the Gordon Research Conferences, the Pediatric Allergy and Asthma Meeting, and the American College of Allergy Asthma and Immunology. AWB is a minority stockholder of both Allertein and Mastcell Pharmaceuticals stock. These interests do not directly relate to the article but are being shared for full disclosure. AWB is an author of references cited in this topic.
J. Andrew Bird, MD
Associate Professor
Department of Pediatrics
Division of Allergy and Immunology
University of Texas Southwestern Medical Center
Dallas
TX
Раскрытие информации
JAB has received personal fees from Food Allergy Research and Education, personal fees and non-financial support from American College of Allergy, Asthma and Immunology, grants from Nestle Health Sciences, personal fees from Nutricia North America, personal fees from Pharm-Olam International LTD, personal fees and other from Pfizer Pharmaceuticals, grants, personal fees and non-financial support from Aimmune Therapeutics, personal fees from Prota Therapeutics, personal fees from Allergy Therapeutics, Ltd, grants from NIH-NIAID, grants from Genentech, personal fees from AllerGenis, personal fees from Abbott Nutrition International, grants and personal fees from DBV Technologies, personal fees from Vincido Medical Education, personal fees from WebMD and grants from Astellas.
Рецензенты
Justin Skripak, MD
Assistant Professor of Pediatric Allergy and Immunology
Mount Sinai School of Medicine
New York
NY
Раскрытие информации
JS declares that he has no competing interests.
Hugh A. Sampson, MD
Professor of Pediatrics
Mount Sinai School of Medicine
New York
NY
Раскрытие информации
HAS holds a 4% interest in a biotech company, Allertein Pharmaceuticals LLC, which is developing an engineered recombinant protein vaccine for peanut allergy, and 45% interest in a virtual company, Herbal Springs LLC, that holds a patent application on an herbal product for treating asthma and another for treating food allergy. HAS is an author of a number of references cited in this topic.
Adam Fox, MA(Hons) Cantab., MSc, MBBS, DCH, FRCPCH, FHEA, Dip. Allergy
Consultant and Honorary Senior Lecturer in Paediatric Allergy
Evelina Children's Hospital
Guy's & St Thomas' Hospitals NHS Foundation Trust
London
UK
Раскрытие информации
AF declares that he has no competing interests.
Использование этого контента попадает под действие нашего заявления об отказе от ответственности