Summary
Definition
History and exam
Key diagnostic factors
- наличие факторов риска
- эритема или изъязвление слизистой полости рта
- боль в ротовой полости
Other diagnostic factors
- нарушение режима питания
- диарея
- лихорадка
Risk factors
- интенсивная схема химиотерапии
- лучевая терапия ротовой полости
- химиолучевая терапия
- генетические полиморфизмы в метаболических ферментах препаратов
Diagnostic investigations
1st investigations to order
- клинический диагноз
Investigations to consider
- ОАК с лейкоцитарной формулой
- бактериологическое исследование крови
- поверхностный мазок поражения для микроскопического исследования
- грибковая культура
- вирусологическое исследование или полимеразная цепная реакция (ПЦР)
Treatment algorithm
проходящие трансплантацию кроветворных стволовых клеток: профилактические мероприятия
прием одноразовой дозы фторурацила: превентивные меры
получение лучевой терапии полости рта: превентивные меры
установленный мукозит полости рта
Contributors
Authors
Rajesh V. Lalla, DDS, PhD, DABOM
Associate Professor
Associate Dean for Research
Section of Oral Medicine
University of Connecticut School of Dental Medicine
Farmington
CT
Disclosures
RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics and Novartis.
Ourania Nicolatou-Galitis, DDS, MSc, DrDent
Professor
Hospital Dentistry
National & Kapodistrian University of Athens
Athens
Greece
Disclosures
ONG has received fees from Angelini pharma to author a review article on oral mucositis. ONG is an author of several references cited in this topic.
Nikolaos Tsoukalas, MD, MSc, PhD
Medical Oncologist
Associate Director
Department of Oncology
401 General Military Hospital
Athens
Greece
Disclosures
NT declares that he has no competing interests.
Acknowledgements
Professor Ourania Nicolatou-Galitis and Dr Nikolaos Tsoukalas would like to gratefully acknowledge Dr Eleni Arvanitou, who contributed to the updating of this topic, and Dr Rajesh V. Lalla, a previous contributor.
Disclosures
EA declares that she has no competing interests. RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics, and Novartis.
Peer reviewers
Michael Brennan, DDS, MHS
Associate Chairman and Oral Medicine Residency Director
Department of Oral Medicine
Carolinas Medical Center
Charlotte
NC
Disclosures
MB is an author of a reference cited in this topic. MB is part of the Mucositis Study Group of MASCC/ISOO, and participated in the review of mucositis.
Maria Michelagnoli, MB ChB, MD, FRCPCH
Consultant Pediatric and Adolescent Oncologist
University College London Hospitals
London
UK
Disclosures
MM declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
Al-Dasooqi N, Sonis ST, Bowen JM, et al. Emerging evidence on the pathobiology of mucositis. Support Care Cancer. 2013 Nov;21(11):3233-41. Abstract
Elad S, Cheng KKF, Lalla RV, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2020 Oct 1;126(19):4423-31.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Кандидоз ротовой полости
- Инфекция вируса простого герпеса
- Болезнь "трансплантат против хозяина".
More Differentials指南
- Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation
- MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy
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