Summary
Definition
History and exam
Key diagnostic factors
- incongruência entre o sexo atribuído ao nascer e o gênero vivenciado
- aparência ou resposta emocional alteradas
Risk factors
- transtorno do espectro autista (TEA)
- hiperplasia adrenal congênita
- síndrome de Klinefelter
Diagnostic investigations
1st investigations to order
- testosterona sérica
- di-hidrotestosterona sérica
- hormônio folículo-estimulante (FSH) e hormônio luteinizante (LH) séricos
- prolactina sérica
- testes séricos da função hepática
- perfil lipídico sérico
- Hemograma completo
Investigations to consider
- antígeno prostático específico (PSA) sérico em indivíduos com sexo atribuído como masculino ao nascer
- 25-hidroxivitamina D sérica
Treatment algorithm
mulheres transgênero (pessoas transgênero de homem para mulher cujo sexo atribuído ao nascer foi masculino)
homens transgêneros (pessoas transgênero de mulher para homem cujo sexo atribuído ao nascer foi feminino)
Contributors
Authors
James Barrett, FRCPsych, BSc, MSc
Consultant Psychiatrist and Lead Clinician
Charing Cross Gender Identity Clinic
London
UK
Disclosures
JB declares that he has no competing interests. JB is an author of a number of references cited in this topic.
Peer reviewers
Leighton John Seal, MBBS, BSC, PhD, FRCP
Consultant and Honorary Reader in Diabetes and Endocrinology
St. George's University Hospital
NHS foundation trust
London
UK
Declarações
LS has received an honorarium for giving a lecture in a non-promotional meeting on the subject of gender dysphoria by Besins healthcare.
Jack Drescher, MD
Clinical Professor of Psychiatry
Columbia University
NY
Declarações
JD declares that he has no competing interests.
Rebecca Luff, BSc(Hons)
Individual with lived experience of gender dysphoria.
Disclosures
RL declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
World Health Organization. International statistical classification of diseases and health related problems (ICD). 11th revision. Jan 2022 [Internet publication].Full text
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition (DSM-5). Washington, DC: American Psychiatric Publishing; 2022.
Coleman E, Radix AE, Bouman WP, et al. Standards of care for the health of transgender and gender diverse people, version 8. Int J Transgend Health. 2022;23(suppl 1):S1-S259.Full text Abstract
Richards C, Barrett J. Trans and Non-binary Gender Healthcare for Psychiatrists, Psychologists, and Other Health Professionals. Cambridge, UK: Cambridge University Press; 2020.
Hembree WC, Cohen-Kettenis PT, Gooren L, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2017 Nov 1;102(11):3869-903. Abstract
The American College of Obstetricians and Gynecologists. Health care for transgender and gender diverse individuals: ACOG Committee Opinion, Number 823. Obstet Gynecol. 2021 Mar 1;137(3):e75-88.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Autoginefilia
- Transtorno dismórfico corporal
- Psicose
More DifferentialsGuidelines
- Diagnostic and Statistical Manual of Mental Disorders, 5th Edition, Text Revision (DSM-5-TR)
- Standards of care version 8
More GuidelinesPatient information
Cuidados de afirmação de gênero em adultos: cirurgia
Cuidados de afirmação de gênero em adultos: tratamento hormonal
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