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Síndrome serotoninérgica

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  • Visão geral
  • Teoria
  • Diagnóstico
  • Tratamento
  • ACOMPANHAMENTO
  • Recursos
ბოლო მიმოხილვა: 4 Feb 2026
ბოლო განახლება: 07 Oct 2022

შეჯამება

განსაზღვრება

ანამნეზი და გასინჯვა

ძირითადი დიაგნოსტიკური ფაქტორები

  • presença de fatores de risco
  • clônus
  • hiper-reflexia
სრული ტექსტი

სხვა დიაგნოსტიკური ფაქტორები

  • ansiedade
  • agitação
  • confusão
  • tremores, espasmos musculares
  • sudorese
  • cefaleia
  • taquicardia
  • hipertonia/rigidez
  • diaforese
  • rubor
  • pupilas dilatadas
  • hipertermia
  • mioclonia
  • estimulação
სრული ტექსტი

რისკფაქტორები

  • exposição a um medicamento serotoninérgico
  • exposição a dois ou mais medicamentos serotoninérgicos
სრული ტექსტი

დიაგნოსტიკური კვლევები

1-ად შესაკვეთი გამოკვლევები

  • diagnóstico clínico
სრული ტექსტი

გასათვალისწინებელი კვლევები

  • Hemograma completo
  • creatina fosfoquinase
  • eletrocardiograma (ECG)
  • hemoculturas
  • punção lombar
  • tomografia computadorizada (TC) ou ressonância nuclear magnética (RNM) do crânio
სრული ტექსტი

მკურნალობის ალგორითმი

მწვავე

toxicidade serotoninérgica grave

toxicidade serotoninérgica moderada

toxicidade serotoninérgica leve

კონტრიბუტორები

ავტორები

Geoffrey Isbister, BSc, MBBS, FACEM, MD

Clinical Toxicologist

Calvary Mater Newcastle

Associate Professor

University of Newcastle

Newcastle

Australia

გაფრთხილება:

GI is an author of several references cited in this monograph.

რეცენზენტები

Laura Tormoehlen, MD, FAAN, FACMT

Neurologist and Medical Toxicologist

Associate Professor of Clinical Neurology and Emergency Medicine

Indiana University

Bloomington

IN

გაფრთხილება:

LT has been compensated as an expert witness for cases involving serotonergic drugs.

Daniel E Brooks, MD

Medical Director

Banner Poison and Drug Information Center

Phoenix

AZ

გაფრთხილება:

DEB declares that he has no competing interests.

Karl Marlowe, MbChB, MSc, PgC-Ed, PgD-CBT, MRCPsych

Consultant Psychiatrist

East London NHS Foundation Trust

London

UK

გაფრთხილება:

KM declares that he has no competing interests.

Theodore A. Stern, MD

Chief

Psychiatric Consultation Service

Massachusetts General Hospital

Professor of Psychiatry

Harvard Medical School

Boston

MA

გაფრთხილება:

TAS declares that he has no competing interests.

Paul M. Gahlinger, MD

Adjunct Professor

Department of Family and Preventive Medicine

University of Utah

Salt Lake City

UT

Disclosures

PMG declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Buckley NA, Dawson AH, Isbister GK. Serotonin syndrome. BMJ. 2014;348:g1626 Abstract

Isbister GK, Buckley NA. The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatment. Clin Neuropharmacol. 2005;28:205-214. Abstract

Dunkley EJ, Isbister GK, Sibbritt D, et al. The Hunter Serotonin Toxicity Criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003;96:635-642.Full text  Abstract

Chiew AL, Buckley NA. The serotonin toxidrome: shortfalls of current diagnostic criteria for related syndromes. Clin Toxicol (Phila). 2022 Feb;60(2):143-58. Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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