Última revisão: 3 Jul 2021
Última atualização: 09 Jan 2020

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • presença de fatores de risco
  • febre
  • erupção cutânea
  • edema
  • volume de urina diminuído

Fatores de risco

  • uso de medicamentos desencadeantes
  • idade
  • doença inflamatória crônica

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • ureia e creatinina séricas
  • hemograma completo com diferencial de leucócitos
  • urinálise
  • teste de descontinuação do medicamento desencadeante
  • anticorpo anticitoplasma de neutrófilo (ANCA)
  • fator antinuclear (FAN)
  • anti-DNA de fita dupla (anti-ds DNA)
  • perfil complementar

Investigações a serem consideradas

  • ultrassonografia renal
  • biópsia renal
  • exame renal com gálio
  • citocinas na urina

Algoritmo de tratamento

Colaboradores

Autores

Mark A. Perazella, MD, FACP

Professor of Medicine (Nephrology)

Section of Nephrology

Department of Internal Medicine

Yale School of Medicine

New Haven

CT

Declarações

MAP declares that he has no competing interests.

Dennis G. Moledina, MBBS, PhD

Assistant Professor of Medicine (Nephrology)

Yale Program of Applied Translational Research

Department of Internal Medicine

Yale School of Medicine

New Haven

CT

Declarações

DGM has received a grant from the National Institutes of Health (K23DK-117065), focusing on biomarkers of acute interstitial nephritis, and is supported by the Yale O'Brien Center, focusing on subclinical acute interstitial nephritis. He has a provisional patent application (co-inventor) for provisional patent number 62/716,465, "System and methods for diagnosing acute interstitial nephritis".

Agradecimentos

Prof. Mark A. Perazella and Dr Dennis G. Moledina would like to gratefully acknowledge Dr James Marsh, Dr Alice Appel, Dr Gerald Appel, and Dr Kate Shiell, previous contributors to this topic.

Declarações

JM, AA, GA, and KS declare that they have no competing interests.

Revisores

Irfan Moinuddin, MD

Assistant Professor

Chicago Medical School

Rosalind Franklin University

Lombard

IL

Declarações

IM declares that he has no competing interests.

Catherine Clase, BA, MB, MSC, FRCPC

Associate Professor

Nephrologist

McMaster University

Hamilton

Ontario

Canada

Declarações

CC declares that she has no competing interests.

Robert Mactier, MD, FRCP

Consultant Nephrologist/Lead Clinician

Renal Unit

Glasgow Royal Infirmary

NHS Greater Glasgow and Clyde

Glasgow

UK

Declarações

RM declares that he has no competing interests.

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