Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- presença de fatores de risco
- febre
- erupção cutânea
- edema
- volume de urina diminuído
Outros fatores diagnósticos
- artralgia
- uveíte
Fatores de risco
- uso de medicamentos desencadeantes
- idade
- doença inflamatória crônica
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- ureia e creatinina séricas
- hemograma completo com diferencial de leucócitos
- urinálise
- teste de descontinuação do medicamento desencadeante
- anticorpo anticitoplasma de neutrófilo (ANCA)
- fator antinuclear (FAN)
- anti-DNA de fita dupla (anti-ds DNA)
- perfil complementar
Investigações a serem consideradas
- ultrassonografia renal
- biópsia renal
- exame renal com gálio
- citocinas na urina
Algoritmo de tratamento
relacionada a medicamentos
relacionada a doença inflamatória crônica
Colaboradores
Autores
Mark A. Perazella, MD, FACP
Professor of Medicine (Nephrology)
Section of Nephrology
Department of Internal Medicine
Yale School of Medicine
New Haven
CT
Declarações
MAP declares that he has no competing interests.
Dennis G. Moledina, MBBS, PhD
Assistant Professor of Medicine (Nephrology)
Yale Program of Applied Translational Research
Department of Internal Medicine
Yale School of Medicine
New Haven
CT
Declarações
DGM has received a grant from the National Institutes of Health (K23DK-117065), focusing on biomarkers of acute interstitial nephritis, and is supported by the Yale O'Brien Center, focusing on subclinical acute interstitial nephritis. He has a provisional patent application (co-inventor) for provisional patent number 62/716,465, "System and methods for diagnosing acute interstitial nephritis".
Agradecimentos
Prof. Mark A. Perazella and Dr Dennis G. Moledina would like to gratefully acknowledge Dr James Marsh, Dr Alice Appel, Dr Gerald Appel, and Dr Kate Shiell, previous contributors to this topic.
Declarações
JM, AA, GA, and KS declare that they have no competing interests.
Revisores
Irfan Moinuddin, MD
Assistant Professor
Chicago Medical School
Rosalind Franklin University
Lombard
IL
Declarações
IM declares that he has no competing interests.
Catherine Clase, BA, MB, MSC, FRCPC
Associate Professor
Nephrologist
McMaster University
Hamilton
Ontario
Canada
Declarações
CC declares that she has no competing interests.
Robert Mactier, MD, FRCP
Consultant Nephrologist/Lead Clinician
Renal Unit
Glasgow Royal Infirmary
NHS Greater Glasgow and Clyde
Glasgow
UK
Declarações
RM declares that he has no competing interests.
Diagnósticos diferenciais
- Glomerulonefrite aguda
- Necrose tubular aguda
- Lesão vascular aguda
Mais Diagnósticos diferenciaisDiretrizes
- Acute kidney injury: prevention, detection and management
- Guidelines for medicines optimisation in patients with acute kidney injury
Mais DiretrizesConectar-se ou assinar para acessar todo o BMJ Best Practice
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