Summary
Definition
History and exam
Key diagnostic factors
- presença de fatores de risco
- lesão cutânea primária
- lesões de linfangite nodulares
Other diagnostic factors
- sintomas respiratórios
- edema/eritema articular
- homens de 30 a 60 anos de idade
- febre
- linfadenopatia
- sintomas tipo meningite
Risk factors
- trauma na pele
- profissões/passatempos em áreas externas
- mordidas e arranhaduras de animais
- transtornos decorrentes do uso de bebidas alcoólicas
- diabetes mellitus
- Vírus da imunodeficiência humana (HIV)/síndrome de imunodeficiência adquirida (AIDS)
- doença pulmonar obstrutiva crônica (DPOC)
- tratamento com corticosteroides
- quimioterapia em pacientes com neoplasia hematológica
- transplante de órgãos sólidos/células-tronco hematopoiéticas
- terapia com inibidor do fator de necrose tumoral alfa (TNF-alfa)
Diagnostic tests
1st tests to order
- cultura fúngica da lesão cutânea
- histopatologia da lesão cutânea (metenamina de prata de Gomori, ácido periódico de Schiff)
- Hemograma completo
- velocidade de hemossedimentação
- radiografia da articulação
- cultura fúngica do líquido sinovial por artrocentese
- cultura fúngica de escarro ou da lavagem broncoalveolar (LBA)
- punção lombar para análise do líquido cefalorraquidiano
- cultura fúngica do líquido cefalorraquidiano (LCR)
- hemoculturas para fungos
Tests to consider
- biópsia de tecido sinovial para cultura fúngica
- histopatologia do tecido sinovial (metenamina de prata de Gomori, coloração com ácido periódico de Schiff)
- cultura fúngica da biópsia brônquica
- histopatologia da biópsia brônquica
- radiografia torácica
- tomografia computadorizada (TC) do tórax
- níveis de itraconazol sérico
- ureia sérica
- creatinina sérica
- TFHs
Emerging tests
- coloração imuno-histoquímica
- reação em cadeia da polimerase
Treatment algorithm
não gestante: linfocutânea/cutânea
não gestante: doença extracutânea leve/moderada
não gestante: doença extracutânea grave/com risco de vida
gestantes: cutânea
gestantes: linfocutânea
gestantes: extracutânea
Contributors
Authors
Michail Lionakis, MD, ScD
Chief
Fungal Pathogenesis Section
Laboratory of Clinical Immunology and Microbiology
National Institutes of Allergy and Infectious Diseases
National Institutes of Health
Bethesda
MD
Disclosures
ML declares that he has no competing interests.
John E. Bennett, MD
Chief
Clinical Mycology Section
Laboratory of Clinical Immunology and Microbiology
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda
MD
Disclosures
JEB declares that he has no competing interests.
Peer reviewers
George Samonis, MD
Professor of Internal Medicine/Infectious Diseases
University of Crete
Department of Internal Medicine
Gallos University Campus
Crete
Greece
Disclosures
GS declares that he has no competing interests.
Amy Xu, MD, MA
Assistant Professor of Medicine
Section of Dermatology
University of Chicago
Chicago
IL
Disclosures
AX declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
Rex JH, Okhuysen PC. Sporothrix schenckii. In Bennett JE, Dolin R, Blaser MJ, eds. Principles and practice of infectious diseases. 9th ed. Philadelphia, PA: Elsevier, 2020: 3131-6.
Orofino-Costa R, Macedo PM, Rodrigues AM, et al. Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics. An Bras Dermatol. 2017 Sep-Oct;92(5):606-20.Full text Abstract
Kauffman CA, Bustamante B, Chapman SW, et al. Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007 Nov 15;45(10):1255-65.Full text Abstract
Sharkey-Mathis PK, Kauffman CA, Graybill JR, et al. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Am J Med. 1993 Sep;95(3):279-85. Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Nocardiose cutânea primária
- Infecção cutânea por Mycobacterium marinum
- Leishmaniose cutânea
More DifferentialsGuidelines
- Clinical practice guidelines for the management of sporotrichosis
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