Summary
Definition
History and exam
Key diagnostic factors
- presença de fatores de risco
- febre
- sintomas constitucionais
- hiperemia conjuntival
- bradicardia relativa (sinal de Faget)
- enfermidade bifásica
- diátese hemorrágica
- sinais de insuficiência renal
- sinais de insuficiência hepática
- icterícia
Other diagnostic factors
- hipotensão
- dor abdominal, vômitos e letargia
Risk factors
- residência ou viagem recente para uma área endêmica
- ausência de vacinação
- picada de mosquito
- viagens durante as estações chuvosas e no início das secas
Diagnostic investigations
1st investigations to order
- Hemograma completo
- testes da função hepática
- coagulograma
- reação em cadeia da polimerase via transcriptase reversa (RT-PCR)
- sorologia
Investigations to consider
- eletrocardiograma (ECG)
- histopatologia
Emerging tests
- isolamento viral
- teste de amplificação isotérmica de ácido nucleico
Treatment algorithm
febre hemorrágica viral não identificada
febre amarela confirmada
Contributors
Authors
William A. Messer, MD, PhD
Associate Professor of Medicine
Department of Molecular Microbiology and Immunology
Division of Infectious Diseases
Oregon Health & Science University
Portland
PortlandOR
Disclosures
WAM declares that he has no competing interests.
Acknowledgements
Dr William A. Messer would like to gratefully acknowledge Dr Philip A. Yeon and Dr Helmut Albrecht, previous contributors to this topic.
Disclosures
PAY and HA declares that he has no competing interests.
Peer reviewers
Carlos Franco-Paredes, MD, MPH
Assistant Professor
Emory University
TravelWell Clinic
Emory University Hospital Midtown
Atlanta
GA
Disclosures
CFP declares that he has no competing interests.
Andrea K. Boggild, MSc, MD, DTMH, FRCPC
Clinical Assistant
Tropical Diseases Unit
Division of Infectious Diseases
Department of Medicine
Toronto General Hospital
University Health Network
Toronto
Canada
Disclosures
AKB declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
World Health Organization. Yellow fever: fact sheet. May 2023 [internet publication].Full text
Staples JE, Bocchini JA Jr, Rubin L; Centers for Disease Control and Prevention (CDC). Yellow fever vaccine booster doses: recommendations of the Advisory Committee on Immunization Practices, 2015. MMWR Morb Mortal Wkly Rep. 2015;64:647-650.Full text Abstract
Pan American Health Organization; World Health Organization. Laboratory diagnosis of yellow fever virus infection. September 2018 [internet publication].Full text
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Febre da dengue
- Malária
- Infecção pelo vírus da Zika
More DifferentialsGuidelines
- CDC Yellow Book: health information for international travel - yellow fever
- Yellow fever: the green book, chapter 35
More Guidelines
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