Summary
Definition
History and exam
Key diagnostic factors
- presença de fatores de risco
- febre
- tosse
- mialgia
- dispneia
Other diagnostic factors
- calafrios
- mal-estar
- cefaleia
- diarreia aquosa
- taquipneia
- taquicardia
- cianose
- náuseas e vômitos
- faringite
- produção de escarro
- dor torácica
- pleurisia
- rinorreia
- tontura
- artralgia
- dor abdominal
- convulsão
- delirium
- estertores
- estertores inspiratórios
- sopro tubário
Risk factors
- viagem para uma área afetada
- contato próximo com uma pessoa infectada
- trabalho laboratorial com SARS-CoV
Diagnostic tests
1st tests to order
- Hemograma completo
- aminotransferases
- lactato desidrogenase
- creatina quinase
- hemocultura
- cultura de escarro
- culturas virais nasofaríngeas
- coloração para anticorpo por imunofluorescência direta
- radiografia torácica
- oximetria de pulso
- reação em cadeia da polimerase via transcriptase reversa (RT-PCR)
Tests to consider
- gasometria arterial
- coagulograma
- tomografia computadorizada de alta resolução (TCAR) do tórax
- teste sorológico para anticorpos específicos para SARS-CoV
- cultura viral
Emerging tests
- imunoensaio rápido com swab para detecção de SARS-CoV
- anticorpos monoclonais
Treatment algorithm
suspeita de síndrome respiratória aguda grave (SARS)
síndrome respiratória aguda grave (SARS) confirmada
Contributors
Authors
Georgia G. Pitsiou, MD, PhD
Associate Professor in Pulmonary Medicine
Aristotle University of Thessaloniki
Respiratory Failure Clinic
General Hospital G. Papanikolaou
Thessaloniki
Greece
Disclosures
GGP declares that she has no competing interests.
Ioannis P. Kioumis, MD, PhD
Professor in Pulmonary Medicine
Infectious Diseases
Aristotle University of Thessaloniki
Respiratory Failure Clinic
General Hospital G. Papanikolaou
Thessaloniki
Greece
Disclosures
IPK declares that he has no competing interests.
Peer reviewers
Tommy R. Tong, MD
Attending Pathologist
Montefiore Medical Center
Bronx
NY
Disclosures
TRT declares that he has no competing interests.
Sian Griffiths, OBE, MA, MB BChir, FFPHM, FRCP (Lon), FRCP (Edin), FHKCCM
Director of the School of Public Health
Chinese University of Hong Kong
Prince of Wales Hospital
New Territories
Hong Kong
Disclosures
SG declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
Christian MD, Poutanen SM, Loutfy MR, et al. Severe acute respiratory syndrome. Clin Infect Dis. 2004;38:1420-1427.Full text Abstract
Peiris JS, Chu CM, Cheng VC, et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003;361:1767-1772. Abstract
Mahony JB, Richardson S. Molecular diagnosis of severe acute respiratory syndrome: the state of the art. J Mol Diagn. 2005;7:551-559. Abstract
Peiris JS, Yuen KY, Osterhaus AD, et al. The severe acute respiratory syndrome. N Engl J Med. 2003;349:2431-2441. Abstract
Fowler RA, Lapinsky SE, Hallet D, et al. Critically ill patients with severe acute respiratory syndrome. JAMA. 2003;290:367-373.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
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