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Colite tóxica e megacólon tóxico

Last reviewed: 16 Jul 2025
Last updated: 29 Jul 2022

Summary

Definition

History and exam

Key diagnostic factors

  • presença de fatores de risco
  • febre/calafrios
  • taquicardia
  • alterações do estado mental
  • hipotensão
  • distensão abdominal
Full details

Other diagnostic factors

  • diarreia
  • dor abdominal
  • desconforto abdominal
Full details

Risk factors

  • colite ulcerativa
  • Colite de Crohn
  • colite pseudomembranosa
  • colite infecciosa
  • vírus da imunodeficiência humana (HIV)/síndrome de imunodeficiência adquirida (AIDS)/imunossupressão
  • descontinuação de medicamentos para tratamento da doença inflamatória intestinal
  • agentes antimotilidade
  • imunossupressão quimioterápica/química
  • anormalidades eletrolíticas
Full details

Diagnostic investigations

1st investigations to order

  • Hemograma completo
  • eletrólitos séricos
  • níveis de albumina sérica
  • ácido lático sérico
  • estudos de fezes
  • tomografia computadorizada (TC) de abdome/pelve
  • radiografia abdominal
  • radiografia torácica
Full details

Investigations to consider

  • proteína C-reativa
  • velocidade de hemossedimentação (VHS)
  • hemoculturas
  • sigmoidoscopia
  • biópsia retal
  • espécime cirúrgico
Full details

Treatment algorithm

ACUTE

todos os pacientes

Contributors

Authors

Jan Rakinic, MD

Chief

Colorectal Surgery

Department of Surgery

Southern Illinois University School of Medicine

Springfield

IL

Disclosures

JR is the President of the American Board of Colon and Rectal Surgery.

V. Prasad Poola, MBBS, FACS, FASCRS

Associate Professor of Surgery

Department of Surgery

Southern Illinois University School of Medicine

Springfield

IL

Divulgaciones

VPP declares that he has no competing interests.

Agradecimientos

Dr Jan Rakinic and Dr V. Prasad Poola would like to gratefully acknowledge Dr Scott A. Strong, Dr Mukta V. Krane, and Dr Alessandro Fichera, previous contributors to this topic.

Divulgaciones

SAS, MVK, and AF declare that they have no competing interests.

Revisores por pares

Sharon Stein, MD

Assistant Professor of Surgery

Division of Colon and Rectal Surgery

University Hospital Case Medical Center

Cleveland

OH

Divulgaciones

SS received a fee for educational courses on laparoscopic surgery, paid for in part by Covidien, Olympus, and Applied Medical.

David J. Hackam, MD, PhD

Associate Professor of Pediatric Surgery

University of Pittsburgh School of Medicine

Pittsburgh

PA

Divulgaciones

DJH declares that he has no competing interests.

James Wheeler, MB, BCh, MD, FRCS

Consultant

Colorectal Surgeon

Addenbrookes Hospital

Cambridge

UK

Divulgaciones

JW declares that he has no competing interests.

Referencias

Nuestros equipos internos de evidencia y editoriales colaboran con colaboradores expertos internacionales y revisores pares para garantizar que brindemos acceso a la información más clínicamente relevante posible.

Artículos principales

Rubin DT, Ananthakrishnan AN, Siegel CA, et al. ACG clinical guideline: ulcerative colitis in adults. Am J Gastroenterol. 2019 Mar;114(3):384-413.Texto completo  Resumen

McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018 Mar 19;66(7):987-94.Texto completo  Resumen

Kelly CR, Fischer M, Allegretti JR, et al. ACG clinical guidelines: prevention, diagnosis, and treatment of Clostridioides difficile infections. Am J Gastroenterol. 2021 Jun 1;116(6):1124-47.Texto completo  Resumen

Lightner AL, Vogel JD, Carmichael JC, et al. The American Society of Colon and Rectal Surgeons clinical practice guidelines for the surgical management of Crohn's disease. Dis Colon Rectum. 2020 Aug;63(8):1028-52.Texto completo  Resumen

Artículos de referencia

Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
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