Резюме
Определение
Анамнез и осмотр
Ключевые диагностические факторы
- presença de fatores de risco
- artralgia
- fraqueza
- vasculite
- púrpura vascular de membros inferiores
Другие диагностические факторы
- neuropatia periférica
- sintomas de secura
- hipertensão
- Fenômeno de Raynaud
- úlceras cutâneas de membros inferiores
- diplopia
- ataxia
- cefaleia
- confusão
- hemorragia retiniana/trombose da veia retiniana
- acrocianose
Факторы риска
- infecção pelo vírus da hepatite C (HCV)
- outras infecções virais
- doenças autoimunes
- distúrbios linfoproliferativos
Диагностические исследования
Исследования, которые показаны в первую очередь
- pesquisa qualitativa de crioglobulinas séricas em jejum
- Hemograma completo
- perfil bioquímico sérico abrangente
- velocidade de hemossedimentação, proteína C-reativa
- urinálise
- eletrocardiograma (ECG)
- radiografia torácica
- fator reumatoide
- componentes CH50, C3, C4 do complemento
- anticorpo do vírus da hepatite C (HCV)
- anticorpo antivírus da hepatite B
Исследования, проведение которых нужно рассмотреть
- anticorpo antivírus da imunodeficiência humana (anti-HIV)
- fator antinuclear (FAN), antígenos da síndrome de Sjögren, anticorpo do antígeno nuclear extraível (ENA)
- biópsia de pele
Алгоритм лечения
crioglobulinemia mista
crioglobulinemia associada à malignidade (tipo I)
Составители
Авторы
Gurjit S. Kaeley, MBBS, MRCP
Professor of Medicine
Chief, Division of Rheumatology and Clinical Immunology
Medical Director, Musculoskeletal Ultrasound Program
Program Director, Rheumatology Fellowship
University of Florida College of Medicine - Jacksonville
Jacksonville
FL
Раскрытие информации
GSK declares that he has no competing interests.
Рецензенты
Morie Gertz, MD
Professor of Medicine
Division of Hematology
Mayo Clinic
Rochester
MN
Раскрытие информации
MG is an author of a number of references cited in this topic.
Antonio Palumbo, MD
Associate Professor
University of Turin
Chief
Myeloma Unit
Ospedale Molinette
Turin
Italy
Раскрытие информации
AP declares that he has no competing interests.
Xavier Leleu, MD, PhD
Instructor in Hematology
Department of Hematology
Hopital Huriez CHRU
Lille
France
Disclosures
XL has received lecture fees and research funding from Janssen-Cilag, Celgene, Chugai, Amgen, Novartis, Mundipharma, and Roche. XL is an author of a number of references cited in this topic.
Rajan Madhok, MD, FCRP
Consultant Physician and Rheumatologist
Centre for Rheumatic Diseases
Glasgow Royal Infirmary
Glasgow
UK
Disclosures
RM declares that he has no competing interests.
References
Key articles
Roccatello D, Saadoun D, Ramos-Casals M, et al. Cryoglobulinaemia. Nat Rev Dis Primers. 2018 Aug 2;4(1):11. Abstract
American Association for the Study of Liver Diseases; Infectious Diseases Society of America. HCV guidance: recommendations for testing, managing, and treating hepatitis C. Oct 2022 [internet publication].Full text
Quartuccio L, Bortoluzzi A, Scirè CA, et al. Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC). Clin Rheumatol. 2023 Feb;42(2):359-70.Full text Abstract
Montero N, Favà A, Rodriguez E, et al. Treatment for hepatitis C virus-associated mixed cryoglobulinaemia. Cochrane Database Syst Rev. 2018 May 7;(5):CD011403.Full text Abstract
Kidney Disease: Improving Global Outcomes (KDIGO) Hepatitis C Work Group. KDIGO 2022 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int. 2022 Dec;102(6s):S129-205.Full text
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Diagnósticos diferenciais
- Vasculite de pequenos a médios vasos
- Criofibrinogenemia
More Diagnósticos diferenciaisDiretrizes
- Management of mixed cryoglobulinemia with rituximab
- HCV guidance: recommendations for testing, managing, and treating hepatitis C
More DiretrizesFolhetos informativos para os pacientes
Linfoma não Hodgkin
Hepatite C: o que é?
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