Summary
Definition
History and exam
Key diagnostic factors
- progressão da doença
- fraqueza
- alterações sensitivas
- redução dos reflexos tendinosos profundos
Other diagnostic factors
- falta de coordenação
- idade entre 40 e 60 anos
- infecção precedente
- ausência de exposição a medicamentos que causam neuropatia
- dispneia
- fraqueza facial
- disartria
- disfagia
- incontinência urinária
- urgência ou hesitação urinária
- impotência
- hipotensão ortostática
- papiledema
- perda da visão
- espasticidade
Risk factors
- sexo masculino
- doenças autoimunes
- diabetes mellitus
- infecção
- gamopatia monoclonal de significado indeterminado (MGUS)
Diagnostic tests
1st tests to order
- estudos da condução nervosa
Tests to consider
- avaliação do líquido cefalorraquidiano (LCR)
- ultrassonografia de nervo
- RNM da coluna vertebral e do plexo com e sem contraste
- protocolo clínico da terapia
- biópsia de nervo
- ensaio de imunoadsorção enzimática (ELISA) ou Western blot para detectar autoanticorpos
- outros testes
Treatment algorithm
sem impacto significativo sobre o funcionamento e a qualidade de vida
impacto significativo sobre o funcionamento e a qualidade de vida
resposta parcial ou ausente à monoterapia inicial
refratário à terapia combinada com 2 agentes iniciais
resposta ao tratamento
ausência de resposta ao tratamento
Contributors
Authors
Karissa L. Gable, MD
Associate Professor of Neurology
Department of Neurology
Duke University School of Medicine
Durham
NC
Disclosures
KLG has taken part in CIDP education events for Medscape/Web MD. KLG is an author of references cited in this topic.
Thapat Wannarong, MD
Fellow of Neurology
Department of Neurology
Duke University School of Medicine
Durham
NC
Disclosures
TW is an author of references cited in this topic.
Acknowledgements
Dr Karissa L. Gable and Dr Thapat Wannarong would like to gratefully acknowledge Professor Glenn Lopate, the previous contributor to this topic.
Disclosures
GL is on the medical advisory board for Alnylam Pharmaceuticals and a consultant for Gerson Lehrman Group. GL is an author of references cited in this topic.
Peer reviewers
Anza B. Memon, MD
Senior Staff Neurologist
Henry Ford Health System
Clinical Assistant Professor
Wayne State University School of Medicine
Detroit
MI
Disclosures
ABM declares that she has no competing interests.
Richard A.C. Hughes, MD, FRCP, FMedSci
Professor
Cochrane Neuromuscular Disease Group
MRC Centre for Neuromuscular Disease
National Hospital for Neurology and Neurosurgery
London
UK
Disclosures
RACH has held or holds consultancies with companies that produce intravenous immunoglobulin (CSL Behring, LFB, Octapharma, Kedrion, and Talecris) and with other companies that produce immunomodulatory drugs (Biogen-Idec and Ares-Serono). RACH has received grants from the UK Department of Health for the Cochrane Neuromuscular Disease Review Group, Sandoz (now Novartis), and Ares-Serono. RACH is an author of a number of references cited in this topic.
Jean-Michel Vallat, MD
Professor
CHU Dupuytren
Service et Laboratoire de Neurologie
Limoges
France
Disclosures
Not disclosed.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
Van den Bergh PYK, van Doorn PA, Hadden RDM, et al. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force - second revision. Eur J Neurol. 2021 Nov;28(11):3556-83.Full text Abstract
Dyck PJB, Tracy JA. History, diagnosis, and management of chronic inflammatory demyelinating polyradiculoneuropathy. Mayo Clin Proc. 2018 Jun;93(6):777-93.Full text Abstract
Broers MC, Bunschoten C, Drenthen J, et al. Misdiagnosis and diagnostic pitfalls of chronic inflammatory demyelinating polyradiculoneuropathy. Eur J Neurol. 2021 Jun;28(6):2065-73.Full text Abstract
Oaklander AL, Lunn MP, Hughes RA, et al. Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews. Cochrane Database Syst Rev. 2017 Jan 13;(1):CD010369.Full text Abstract
Mahdi-Rogers M, Brassington R, Gunn AA, et al. Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory demyelinating polyradiculoneuropathy. Cochrane Database Syst Rev. 2017 May 8;(5):CD003280.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Síndrome de Guillain-Barré (GBS)
- Doença de Charcot-Marie-Tooth (CMT)
- Neuropatia de antiglicoproteína associada à mielina (anti-MAG)
More DifferentialsGuidelines
- European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force - second revision
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