Summary
Definition
History and exam
Key diagnostic factors
- presença de fatores de risco
- febre baixa
- vesículas e úlceras orais
- erupção cutânea e/ou vesículas nas mãos e pés
Other diagnostic factors
- mal-estar
- ferida na boca
- perda de apetite
- faringite
- erupção cutânea e/ou vesículas nas nádegas
- dor abdominal
- diarreia
- tosse
- eritema/edema na língua
- artralgia
Risk factors
- imunossupressão
- idade <10 anos
- contatos na família ou na escola com infecção
Diagnostic tests
Tests to consider
- cultura viral
- Hemograma completo
Emerging tests
- ensaios moleculares por reação em cadeia da polimerase
Treatment algorithm
todos os pacientes
Contributors
Authors
Malobi I. Ogboli, MBBS, FRCP
Consultant Dermatologist
Birmingham Children's Hospital and Birmingham City Hospital
Birmingham
UK
Disclosures
MIO declares that she has no competing interests.
Peer reviewers
Helen Goodyear, MBChB, MRCP, FRCPCH, MD, MMed
Consultant Paediatrician
Heartlands Hospital
Birmingham
UK
Disclosures
HG declares that she has no competing interests.
Andrew Riordan, MD, FRCPCH, MRCP, DTM&H
Consultant in Paediatric Infectious Diseases and Immunology
Royal Liverpool Children's Hospital (Alder Hey)
Liverpool
UK
Disclosures
AR declares that he has no competing interests.
David Cassarino, MD, PhD
Assistant Professor
Department of Pathology and Laboratory Medicine
University of California
Los Angeles
CA
Disclosures
DC declares that he has no competing interests.
Leonid Izikson, MD
Staff Dermatologist
Department of Dermatology
Massachusetts General Hospital
Boston
MA
Disclosures
LI declares that he has no competing interests.
Aisha Sethi, MD
Assistant Professor of Medicine
Associate Residency Program Director
University of Chicago
Chicago
IL
Disclosures
AS declares that she has no competing interests.
References
Key articles
Alsop J, Flewett TH, Foster JR. "Hand-foot-and-mouth disease" in Birmingham in 1959. Br Med J. 1960;2:1708-1711.Full text Abstract
Ishimaru Y, Nakano S, Yamaoka K, et al. Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system. Arch Dis Child. 1980;55:583-588.Full text Abstract
Saguil A, Kane SF, Lauters R, et al. Hand-foot-and-mouth disease: rapid evidence review. Am Fam Physician. 2019 Oct 1;100(7):408-14.Full text Abstract
Chang LY, Tsao KC, Hsia SH, et al. Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. JAMA. 2004;291:222-227.Full text Abstract
Chang LY, Lin TY, Huang YC, et al. Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998. Pediatr Infect Dis J. 1999;18:1092-1096. Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Estomatite aftosa ou úlceras aftosas orais
- Herpes simples
- Herpangina
More DifferentialsGuidelines
- Health protection in children and young people settings, including education
- Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition)
More Guidelines
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