Summary
Definition
History and exam
Key diagnostic factors
- contato próximo com outros indivíduos infectados
- eritema macular vermelho-vivo em ambas as bochechas, não afetando o dorso do nariz e as áreas periorais
- máculas e pápulas eritematosas que formam eritema reticular de aspecto rendilhado, mais claramente observadas nos membros
- imunodeficiência
Other diagnostic factors
- artralgia/artrite
- pródromo (febre, cefaleia, faringite, coriza, dor abdominal)
- sintomas de anemia
Risk factors
- contato próximo com outros indivíduos infectados
- imunodeficiência
- 6 a 10 anos de idade
Diagnostic investigations
1st investigations to order
- diagnóstico clínico
Investigations to consider
- Hemograma completo
- contagem de reticulócitos
- sorologia
- ensaios de ácido desoxirribonucleico (DNA)
Treatment algorithm
febre
artrite secundária
infecção persistente (>3 semanas) por parvovírus B19
Contributors
Authors
Joseph M. Lam, MD
Clinical Associate Professor, Department of Pediatrics
Associate Member, Department of Dermatology and Skin Sciences
University of British Columbia, BC Children’s Hospital
Vancouver
BC
Canada
Disclosures
JML declares that he has no relevant competing interests.
Alexander K. C. Leung, MD
Department of Pediatrics
The University of Calgary, Alberta Children's Hospital
Calgary
Alberta
Canada
Disclosures
AKCL declares that he has no relevant competing interests.
Acknowledgements
Dr Joseph M. Lam and Dr Alexander Leung would like to gratefully acknowledge Dr Kari L. Martin, Dr Christine T. Lauren, Dr Jon Dyer, and Dr Jennifer Holman, the previous contributors to this topic. KLM has served as a board member for Women's Dermatologic Society and American Contact Dermatitis Society. CTL, JD, and JH declare that they have no competing interests.
Peer reviewers
Nevio Cimolai, MD
Professor
Department of Pathology and Laboratory Medicine
Children's and Women's Health Centre of British Columbia
Vancouver
Canada
Disclosures
NC declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
Young NS, Brown KE. Parvovirus B19. N Engl J Med. 2004;350:586-597. Abstract
UK Health Security Agency. Parvovirus B19: guidance, data and analysis. Aug 2024 [internet publication].Full text
Cherry JD. Parvovirus infections in children and adults. Adv Pediatr. 1999;46:245-69. Abstract
Kimberlin DW, Banerjee R, Barnett ED, et al. Red book: 2024-2027 report of the Committee on Infectious Diseases. 33rd ed. Elk Grove Village, IL: American Academy of Pediatrics; 2024.
Centers for Disease Control and prevention. Parvovirus B19 and fifth disease. Nov 2019 [internet publication].Full text
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
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