When viewing this topic in a different language, you may notice some differences in the way the content is structured, but it still reflects the latest evidence-based guidance.

Síndrome da dor regional complexa

Last reviewed: 19 Mar 2025
Last updated: 01 Aug 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presença de fatores de risco
  • dor crônica
  • dor do membro com radiação
  • alodinia e hiperalgesia
  • alterações no esquema corporal
  • edema
  • alterações tróficas na pele e na unha
  • eritema ou aparência azulada
  • alterações locais ou assimetria na sudorese
  • fraqueza muscular
Full details

Other diagnostic factors

  • tremores
  • postura distônica
  • contraturas
  • perda sensorial em distribuição em luva ou meia
  • alterações locais no crescimento capilar
  • bolhas na pele
Full details

Risk factors

  • trauma
  • imobilização
  • sexo feminino
Full details

Diagnostic investigations

1st investigations to order

  • nenhum exame é necessário: o diagnóstico é clínico.
Full details

Investigations to consider

  • eletromiografia
  • estudos da condução nervosa com eletrodos de superfície
  • biópsia por punção cutânea
  • radiografia do membro afetado
  • cintilografia óssea com tecnécio-99m
  • absorciometria por dupla emissão de raios X (DEXA)
  • TC quantitativa
  • RNM
  • estudos vasculares
  • bloqueios do nervo simpático
  • bloqueios anestésicos seletivos ou regionais intravenosos
Full details

Emerging tests

  • teste autonômico

Treatment algorithm

ONGOING

síndrome da dor regional complexa (CRPS) precoce (dentro de 6 meses a partir do início)

síndrome da dor regional complexa (CRPS) crônica (>6 meses desde o início)

Contributors

Authors

Anuj Aggarwal, MD

Clinical Assistant Professor

Anesthesiology, perioperative and pain medicine

Stanford University

Redwood City

CA

Disclosures

AA declares that he has no competing interests.

Acknowledgements

Dr Anuj Aggarwal would like to gratefully acknowledge Dr Nicholas Shenker, Dr Gaurav Chhabra, and Dr Steven H. Horowitz, previous contributors to this topic.

Disclosures

NS is medical adviser to Cambridge Nutraceuticals with stock options. He has received consultancy fees from Roche to provide unrestricted sponsored educational meetings, and grants from Versus Arthritis, the National Institute for Health Research Clinical Research Network, and the Medical Research Council. NS is an author of references cited in this topic. GC has been sponsored by Medtronic, Boston Scientific, Abbott, Nevro, Stimwave, and Polar Medical for attending various conferences and cadaveric workshops relevant to pain medicine and neuromodulation. GC is an associate examiner for the European Society of Regional Anaesthesia & Pain Therapy European Diploma of Pain Medicine exam and is also the regional advisor for pain medicine for the South West Severn deanery. SHH declares that he has no competing interests.

Peer reviewers

Andre Tomasino, MD

Department of Neurological Surgery

Weill Cornell Medical College

New York-Presbyterian Hospital

New York

NY

Disclosures

AT declares that he has no competing interests.

Ari Weinreb, MD, PhD

Associate Chief of Rheumatology

VA Greater Los Angeles Healthcare System

Associate Professor of Medicine

David Geffen School of Medicine

UCLA

Los Angeles

CA

Disclosures

AW declares that he has no competing interests.

Jonathan Berman, MBBS

Consultant in Pain Management and Anaesthesia

Pain Management Department

Royal National Orthopaedic Hospital NHS Trust

Middlesex

UK

Disclosures

JB has been reimbursed by Pfizer for lectures given at Pfizer-sponsored meetings and courses.

  • Síndrome da dor regional complexa images
  • Differentials

    • Infecção
    • Comprometimento arterial
    • Patologia óssea
    More Differentials
  • Guidelines

    • Complex regional pain syndrome: practical diagnostic and treatment guidelines, 5th edition
    • Neuropathic pain in adults: pharmacological management in non-specialist settings
    More Guidelines
  • padlock-lockedLog in or subscribe to access all of BMJ Best Practice

Use of this content is subject to our disclaimer