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Acantose nigricans

Última revisão: 23 Sep 2025
Última atualização: 13 Dec 2024

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • presença de fatores de risco
  • ascendência negra ou hispânica
  • novas lesões aveludadas pigmentadas nas axilas ou nas áreas flexoras
  • lesões distribuídas na parte posterior do pescoço, axilas, vulva, umbigo, parte interna das coxas e virilha
  • ganho de peso
  • distribuição generalizada
  • surgimento súbito de várias ceratoses seborreicas
Detalhes completos

Outros fatores diagnósticos

  • idade >40 anos
  • criança/adulto jovem
  • sexo feminino
  • acrocórdones
  • distribuição acral
  • prurido
  • lesões nas mucosas e palmoplantares
  • perda de peso
Detalhes completos

Fatores de risco

  • obesidade
  • resistência insulínica
  • história familiar positiva de acantose nigricans ou síndrome genética
  • história familiar de diabetes mellitus
  • neoplasia maligna
  • medicamento
Detalhes completos

Диагностические исследования

Исследования, проведение которых нужно рассмотреть

  • glicemia de jejum
  • insulina no sangue em jejum
  • tomografia computadorizada (TC) abdominal
  • biópsia de pele
Полная информация

Алгоритм лечения

ПРОДОЛЖЕНИЕ

apresentação inicial com causa subjacente

não resolvida apesar do tratamento da causa subjacente, hereditária ou idiopática

Составители

Авторы

David S. Cassarino, MD, PhD

Consultant Dermatopathologist

Southern California Permanente Medical Group

Sunset Medical Center

Los Angeles

CA

Раскрытие информации

DSC declares that he has no competing interests.

Выражение благодарностей

Dr David Cassarino would like to gratefully acknowledge Dr Laura Westerling for her contribution to this topic. LNW declares that she has no competing interests.

Рецензенты

Christine Ko, MD

Assistant Professor of Dermatology

Department of Dermatology

Yale University

New Haven

CT

Раскрытие информации

CK declares that she has no competing interests.

John English, MBBS, FRCP

Consultant Dermatologist

Department of Dermatology

Queen's Medical Centre

Nottingham University Hospitals

Nottingham

UK

Раскрытие информации

JE declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Основные статьи

Das A, Datta D, Kassir M, et al. Acanthosis nigricans: a review. J Cosmet Dermatol. 2020 Aug;19(8):1857-65. Аннотация

Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol. 1994 Jul;31(1):1-19. Аннотация

Patel NU, Roach C, Alinia H, et al. Current treatment options for acanthosis nigricans. Clin Cosmet Investig Dermatol. 2018 Aug 7:11:407-13.Полный текст  Аннотация

Статьи, указанные как источники

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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