Resumen
Definición
Anamnesis y examen
Principales factores de diagnóstico
- maior predisposição em certos grupos étnicos/geográficos
- úlceras orais
- úlceras genitais
- uveíte
- lesões de acne
- eritema nodoso
- duração limitada dos sintomas
- tromboflebite superficial
- hipópio
- acidente vascular cerebral (AVC)
- dor ocular, visão turva, fotofobia ou fotossensibilidade
- perda de memória
- cefaleia, confusão ou febre
- hemoptise, tosse, dispneia ou dor torácica
- vermelhidão ou lacrimejamento nos olhos
- comprometimento da fala, do equilíbrio ou dos movimentos
Otros factores de diagnóstico
- dores abdominais do tipo cólica, diarreia ou ulceração gastrointestinal
Factores de riesgo
- idade de 20-40 anos
- história familiar de síndrome de Behçet
- predisposição genética
Pruebas diagnósticas
Pruebas diagnósticas que deben considerarse
- teste de patergia
- fator reumatoide
- fatores antinucleares
- anticorpos anticitoplasma de neutrófilos
- antígeno leucocitário humano B51 (HLA-B51)
- punção lombar
- ressonância nuclear magnética (RNM), angiografia do cérebro por RNM com contraste
- colonoscopia
- endoscopia digestiva alta
- tomografia computadorizada (TC) de alta resolução do tórax
- angiotomografia do tórax
- angiografia pulmonar
Pruebas emergentes
- anticorpos anti-Saccharomyces cerevisiae
Algoritmo de tratamiento
úlceras mucocutâneas
comprometimento ocular
envolvimento gastrointestinal
comprometimento do sistema nervoso central
comprometimento vascular maior
Colaboradores
Autores
Yusuf Yazici, MD
Clinical Associate Professor of Medicine
New York University School of Medicine
Director
Behcet's Syndrome Center
New York University School of Medicine
NY
Divulgaciones
YY has received research support from Amgen, Genentech, and Bristol-Myers Squibb. YY is a consultant for Bristol-Myers Squibb Chugai, Hemay, and Amgen. He is an author of some of the references cited in this topic.
Revisores por pares
Izzet Fresko, MD
Associate Professor of Medicine
Department of Rheumatology
Cerrahpasa Medical Faculty
Istanbul
Turkey
Divulgaciones
IF declares that he has no competing interests.
Megan E.B. Clowse, MD, MPH
Assistant Professor of Medicine
Division of Rheumatology and Immunology
Duke University Medical Center
Durham
NC
Divulgaciones
MEBC has received speaking fees from Abbott Pharmaceuticals.
Philip Seo, MD, MHS
Assistant Professor of Medicine
Division of Rheumatology
Johns Hopkins University School of Medicine
Co-Director
Johns Hopkins Vasculitis Center
Baltimore
MD
Divulgaciones
PS declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Referencias
Artículos principales
Kural-Seyahi E, Fresko I, Seyahi N, et al. The long-term mortality and morbidity of Behcet's syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center. Medicine (Baltimore). 2003 Jan;82(1):60-76. Resumen
International Study Group for Behcet's Disease. Criteria for diagnosis of Behcet's disease. Lancet. 1990 May 5;335(8697):1078-80. Resumen
Hatemi G, Christensen R, Bang D, et al. 2018 update of the EULAR recommendations for the management of Behçet's syndrome. Ann Rheum Dis. 2018 Jun;77(6):808-18.Texto completo Resumen
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
Diferenciales
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Más DiferencialesGuías de práctica clínica
- 2018 update of the EULAR recommendations for the management of Behçet's syndrome
- Criteria for diagnosis of Behcet's disease
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