Última revisão: 1 Fev 2021
Última atualização: 01 Nov 2018

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • presença de fatores de risco
  • dorsalgia inflamatória
  • irite/uveíte
  • entesite
  • apresentação no final da adolescência e logo após os 20 anos
  • sexo masculino
  • história familiar positiva de EA

Outros fatores diagnósticos

  • fadiga
  • perturbação do sono
  • sensibilidade na articulação sacroilíaca
  • dispneia
  • perda de lordose lombar
  • comprometimento das articulações periféricas
  • cifose
  • psoríase
  • sintomas de doença inflamatória intestinal

Fatores de risco

  • HLA (antígeno leucocitário) B27
  • genes aminopeptidase 1 do retículo endoplasmático (ERAP1) e receptor de interleucina 23 (IL23R)
  • história familiar positiva de EA
  • Klebsiella pneumoniae

Investigações diagnósticas

Investigações a serem consideradas

  • HLA (antígeno leucocitário) B27
  • RNM
  • radiografia da coluna cervical (lateral)
  • radiografia da coluna lombar (lateral)
  • radiografia da coluna torácica (lateral)
  • ultrassonografia

Algoritmo de tratamento

Colaboradores

Consultant

Rheumatology Department

Royal Berkshire NHS Foundation Trust

Reading

UK

Declarações

AC has served on the advisory boards for MSD and Sanofi; contributed to educational events for Janssen, MSD, Novartis, and Celgene; been on the speaker bureau for Janssen, Pfizer, and Novartis; and received travel grants from Abbvie, UCB, and Pfizer to attend educational conferences.

Specialist Registrar in Rheumatology

Royal Berkshire NHS Foundation Trust

Reading

UK

Declarações

JG declares that she has no competing interests.

Dr Antoni Chan and Dr Jessica Gunn would like to gratefully acknowledge Dr Sarah Keidel, Dr Millicent Stone, Dr Raj Sengupta, Dr Athimalaipet V. Ramanan, and Dr Emma Pomeroy, the previous contributors to this topic. SK declares that she has no competing interests. MS is an author of several references cited in this topic. RS declares that he has no competing interests. AR declares that he has no competing interests. EP is an author of a reference cited in this topic.

RevisoresVER TUDO

Professor of Rheumatology

Centre for Rheumatic Diseases

University Department of Medicine

Glasgow Royal Infirmary University Trust

Glasgow

UK

Declarações

RS is an author of a reference cited in this topic.

Consultant Physician and Rheumatologist

Northwick Park Hospital

Harrow

UK

Declarações

AK declares that he has no competing interests.

Consultant

Norfolk and Norwich University Hospital

Norwich and the Cromer & District Hospital

Cromer

UK

Declarações

KG is an author of a reference cited in this topic.

Interventional Spine Physiatrist

Pain Medicine Specialist

Medical Director

Spine Center

Lahey Clinic

Burlington

MA

Declarações

AGC declares that he has no competing interests.

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