Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- presença de fatores de risco
- dorsalgia inflamatória
- irite/uveíte
- entesite
- apresentação no final da adolescência e logo após os 20 anos
- sexo masculino
- história familiar positiva de EA
Outros fatores diagnósticos
- fadiga
- perturbação do sono
- sensibilidade na articulação sacroilíaca
- dispneia
- perda de lordose lombar
- comprometimento das articulações periféricas
- cifose
- psoríase
- sintomas de doença inflamatória intestinal
Fatores de risco
- HLA (antígeno leucocitário) B27
- genes aminopeptidase 1 do retículo endoplasmático (ERAP1) e receptor de interleucina 23 (IL23R)
- história familiar positiva de EA
- Klebsiella pneumoniae
Investigações diagnósticas
Investigações a serem consideradas
- HLA (antígeno leucocitário) B27
- RNM
- radiografia da coluna cervical (lateral)
- radiografia da coluna lombar (lateral)
- radiografia da coluna torácica (lateral)
- ultrassonografia
Algoritmo de tratamento
Colaboradores
Autores
Consultant
Rheumatology Department
Royal Berkshire NHS Foundation Trust
Reading
UK
Declarações
AC has served on the advisory boards for MSD and Sanofi; contributed to educational events for Janssen, MSD, Novartis, and Celgene; been on the speaker bureau for Janssen, Pfizer, and Novartis; and received travel grants from Abbvie, UCB, and Pfizer to attend educational conferences.
Specialist Registrar in Rheumatology
Royal Berkshire NHS Foundation Trust
Reading
UK
Declarações
JG declares that she has no competing interests.
Dr Antoni Chan and Dr Jessica Gunn would like to gratefully acknowledge Dr Sarah Keidel, Dr Millicent Stone, Dr Raj Sengupta, Dr Athimalaipet V. Ramanan, and Dr Emma Pomeroy, the previous contributors to this topic. SK declares that she has no competing interests. MS is an author of several references cited in this topic. RS declares that he has no competing interests. AR declares that he has no competing interests. EP is an author of a reference cited in this topic.
Revisores
Professor of Rheumatology
Centre for Rheumatic Diseases
University Department of Medicine
Glasgow Royal Infirmary University Trust
Glasgow
UK
Declarações
RS is an author of a reference cited in this topic.
Consultant Physician and Rheumatologist
Northwick Park Hospital
Harrow
UK
Declarações
AK declares that he has no competing interests.
Consultant
Norfolk and Norwich University Hospital
Norwich and the Cromer & District Hospital
Cromer
UK
Declarações
KG is an author of a reference cited in this topic.
Interventional Spine Physiatrist
Pain Medicine Specialist
Medical Director
Spine Center
Lahey Clinic
Burlington
MA
Declarações
AGC declares that he has no competing interests.
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