Síndrome de Felty
Summary
Definition
History and exam
Key diagnostic factors
- presença de fatores de risco
- esplenomegalia
- deformidades articulares
Other diagnostic factors
- nódulos reumatoides
- hepatomegalia
- história de vasculite
- infecções cutâneas e do trato respiratório frequentes
Risk factors
- artrite reumatoide (AR) >10 anos
- história familiar de AR
- idade >50 anos
- etnia branca
Diagnostic investigations
1st investigations to order
- Hemograma completo
- esfregaço de sangue periférico
- velocidade de hemossedimentação sérica
- proteína C-reativa sérica
- TFHs
- fator reumatoide sérico
Investigations to consider
- fatores antinucleares séricos
- níveis de anticorpos séricos antipeptídeos citrulinados cíclicos (anti-CCP)
- ultrassonografia do abdome
- tomografia computadorizada (TC) do abdome
- radiografia torácica
- biópsia da medula óssea
- exames virológicos
Treatment algorithm
todos os pacientes
Contributors
Authors
Dobrina N. Hull, MA, MRCP, PhD
Consultant Rheumatologist
Kingston Hospital
Kingston upon Thames
UK
Disclosures
DH declares that she has no competing interests.
Acknowledgements
Dr Dobrina N. Hull would like to gratefully acknowledge Dr Gerald Coakley, a previous contributor to this topic. GC is the author of one reference cited in this topic and has been reimbursed by Novartis to attend an educational conference in the UK.
同行评议者
Simon Bowman, PhD, FRCP
Consultant Rheumatologist and Honorary Senior Clinical Lecturer in Rheumatology
Selly Oak Hospital
Birmingham
UK
利益声明
SB declares that he has no competing interests.
Alice Klinkhoff, MD, FRCPC
Medical Director
Mary Pack Arthritis Program
Clinical Associate Professor
University of British Columbia
Vancouver
BC
Canada
Disclosures
AK is the author of a study referenced in this topic.
Alan Bridges, MD
Professor and Vice Chair
Department of Medicine
University of Wisconsin Hospital
Madison
WI
Disclosures
AB declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
Felty AR. Chronic arthritis in the adult associated with splenomegaly and leucopenia. Bull Johns Hopkins Hosp. 1924;35:16-20.
Campion G, Maddison PJ, Goulding N, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features, and immunogenetic associations. Medicine (Baltimore). 1990;69:69-80. Abstract
Balint GP, Balint PV. Felty's syndrome. Best Pract Res Clin Rheumatol. 2004 Oct;18(5):631-45. Abstract
Rashba EJ, Rowe JM, Packman CH. Treatment of the neutropenia of Felty syndrome. Blood Rev. 1996 Sep;10(3):177-84.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Síndrome linfocítica granular grande (LGG)
- Distúrbios linfoproliferativos
- Doenças mieloproliferativas
More DifferentialsGuidelines
- Guideline for vaccinations in patients with rheumatic and musculoskeletal diseases
More GuidelinesPatient information
Artrite reumatoide
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