Síndrome carcinoide
Summary
Definition
History and exam
Key diagnostic factors
- diarreia
- rubor
Other diagnostic factors
- palpitações
- cólicas abdominais
- telangiectasia
- sinais de insuficiência cardíaca direita
- sopros cardíacos
- hepatomegalia
- sibilo
- pelagra
- massas abdominais
Risk factors
- síndrome da neoplasia endócrina múltipla genética tipo 1 (NEM-1)
Diagnostic investigations
1st investigations to order
- cromogranina A/B sérica
- ácido 5-hidroxi-indolacético urinário
- perfil metabólico
- testes da função hepática
- hemograma completo
Investigations to consider
- tomografia computadorizada (TC) do tórax, abdome e pelve com duas fases hepáticas
- broncoscopia
- endoscopia
- cintilografia com receptores de somatostatina ± TC por emissão de fóton único (SPECT) de somatostatina
- cintilografia com iodo I-123 metaiodobenzilguanidina (MIBG)
- histologia
- tomografia por emissão de pósitrons com receptor de somatostatina (SSTR-PET) ou 18-fluordesoxiglucose (FDG)
Treatment algorithm
doença localizada
doença metastática
Contributors
Authors
Rajaventhan Srirajaskanthan, BSc (Hons), MD (Res), FRCP
Consultant Gastroenterologist
Neuroendocrine Tumour Unit
Kings College Hospital
London
UK
Disclosures
RS has received research grants from Novartis and Ipsen, and has attended advisory boards for Novartis, Ipsen and ITM.
Martyn Caplin, BSc, DM, FRCP
Professor
Consultant in Hepatobiliary and Gastroenterology
Neuroendocrine Tumour Unit
Royal Free Hospital
London
UK
Disclosures
MC is on the advisory boards for Novartis, Ipsen, Lexicon, and Pfizer; he has also received speaker honoraria from them.
Peer reviewers
Wail Malaty, MD
Clinical Professor
Department of Family Medicine
University of North Carolina
Chapel Hill
Assistant Program Director
MAHEC Rural Family Medicine Residency
Hendersonville
NC
Disclosures
WM declares that he has no competing interests.
Rajesh K. Garg, MD
Instructor in Medicine
Brigham and Women's Hospital
Division of Endocrinology
Diabetes and Hypertension
Boston
MA
Disclosures
RKG declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors [internet publicaton].Full text
North American Neuroendocrine Tumor Society. NANETS guidelines. 2022 [internet publication].Full text
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Síndrome do intestino irritável (SII)
- Doença de Crohn
- Menopausa
More DifferentialsGuidelines
- NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
- European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma
More GuidelinesPatient information
Câncer de intestino: devo fazer rastreamento?
Câncer de intestino: quais são as opções de tratamento?
More Patient information
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