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Carcinoma basocelular

  • Overview
  • Theory
  • Diagnosis
  • Management
  • Follow up
  • Resources
最后审阅： 24 Sep 2025
最后更新： 20 Feb 2025

小结

定义

病史和体格检查

关键诊断因素

  • presença de fatores de risco
  • pápulas com telangiectasias associadas
  • placas, nódulos e tumores com bordas arredondadas
  • pequenas crostas e feridas que não cicatrizam
  • crostas que não cicatrizam
  • pápulas e/ou placas peroladas
完整详情

其他诊断因素

  • metástases associadas a carcinoma basocelular (CBC) grande ou negligenciado
  • destruição local com lesão avançada
完整详情

危险因素

  • Radiação ultravioleta (UV)
  • exposição ao sol
  • exposição a raios-X
  • exposição a arsênico
  • vias aberrantes de sinalização hedgehog
  • xeroderma pigmentoso
  • síndrome do carcinoma basocelular nevóide (Gorlin-Goltz)
  • história de câncer de pele não melanoma
  • sobreviventes de câncer na infância
  • receptor de transplante
完整详情

诊断性检查

首要检查

  • biópsia para dermato-histopatologia
完整详情

新兴检查

  • microscopia multifóton in vivo

治疗流程

初步治疗

síndrome do carcinoma basocelular nevóide (Gorlin-Goltz)

急症处理

subtipo de baixo risco em localização esteticamente favorável

subtipo de baixo risco em localizações esteticamente desfavoráveis

subtipo de alto risco

持续性治疗

margens positivas no procedimento inicial

carcinomas basocelulares (CBCs) recorrentes complicados e/ou local não acessível a terapias cirúrgicas e tópicas

doença avançada

撰稿人

作者

Robert A. Schwartz, MD, MPH, DSc (Hon), MAE, FAAD, FRCP (Edin)
Robert A. Schwartz

Professor & Head

Dermatology

Rutgers University New Jersey Medical School

Newark

NJ

利益声明

RAS declares that he has no competing interests. RAS is an author of a number of references cited in this topic.

鸣谢

Professor Robert A. Schwartz would like to gratefully acknowledge Dr James R. DeBloom and Dr Drazen Jukic, the previous contributors to this topic.

Раскрытие информации

JRD and DJ declare that they have no competing interests.

Рецензенты

Richard Bull, BMBCh

Consultant Dermatologist

Homerton University Hospital NHS Foundation Trust

London

UK

Раскрытие информации

RB declares that he has no competing interests.

David Cassarino, MD, PhD

Assistant Professor

Department of Pathology and Laboratory Medicine

University of California

Los Angeles

CA

Раскрытие информации

DC declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

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Основные статьи

Nasr I, McGrath EJ, Harwood CA, et al; British Association of Dermatologists' Clinical Standards Unit. British Association of Dermatologists guidelines for the management of adults with basal cell carcinoma 2021. Br J Dermatol. 2021 Nov;185(5):899-920.Полный текст  Аннотация

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: basal cell skin cancer [internet publication].Полный текст

Kim JYS, Kozlow JH, Mittal B, et al; Work Group, Invited Reviewers. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol. 2018 Mar;78(3):540-59.Полный текст  Аннотация

Thomson J, Hogan S, Leonardi-Bee J, et al. Interventions for basal cell carcinoma of the skin. Cochrane Database Syst Rev. 2020 Nov 17;(11):CD003412.Полный текст  Аннотация

Статьи, указанные как источники

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