Última revisão: 16 Abr 2021
Última atualização: 15 Out 2019

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • presença de fatores de risco
  • história familiar de início prematuro de doença coronariana ou dislipidemia em familiares de primeiro grau
  • história de doença cardiovascular
  • consumo de gorduras saturadas e ácidos graxos trans
  • peso corporal excessivo (especialmente a obesidade abdominal)
  • xantelasmas
  • xantomas tendinosos

Outros fatores diagnósticos

  • arco corneano com início antes dos 45 anos de idade
  • xantomas tuberosos

Fatores de risco

  • resistência insulínica e diabetes mellitus do tipo 2
  • excesso de peso corporal (índice de massa corporal >25 kg/m²)
  • tabagismo
  • hipotireoidismo
  • doença hepática colestática
  • síndrome nefrótica
  • uso de determinados medicamentos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • perfil lipídico
  • hormônio estimulante da tireoide (TSH) sérico
  • lipoproteína(a)

Algoritmo de tratamento

Colaboradores

Raul D. Santos

Associate Professor of Medicine

Director Lipid Clinic Heart Institute (InCor)

University of Sao Paulo Medical School Hospital

Scientific Advisor

Hospital Israelita Albert Einstein

Sao Paulo

Brazil

Declarações

RDS has received honoraria for consulting, speaker activities and research from Astra Zeneca, Amgen, Akcea, Biolab, Esperion, Kowa, Pfizer, Merck, Novo-Nordisk, and Sanofi/Regeneron.

Seth S. Martin

Associate Professor of Medicine/Cardiology

Director

Lipid Clinic

Ciccarone Center for the Prevention of Cardiovascular Disease

Division of Cardiology, Department of Medicine

Johns Hopkins University School of Medicine

Baltimore

MD

Declarações

SSM has received honoraria from the American College of Cardiology for educational activities. SSM is listed as a co-inventor on a pending patent filed by Johns Hopkins University for a novel method of LDL-cholesterol estimation. SSM received a charitable gift for the VLDL big data project from the David and June Trone Family Foundation, and has also received research support from the PJ Schafer Cardiovascular Research Fund, American Heart Association, Aetna Foundation, iHealth, Stanford MedX/Nokia, Google, and Apple. SSM has acted as a consultant for Abbott Nutrition, Pressed Juicery, Quest Diagnostics, Sanofi/Regeneron, Amgen, Novo Nordisk, Esperian, Akcea, and the Pew Institute.

Rhanderson Cardoso

Cardiovascular Fellow

Pollin Prevention Fellow

Ciccarone Center for the Prevention of Cardiovascular Disease

Division of Cardiology, Department of Medicine

Johns Hopkins University School of Medicine

Baltimore

MD

Declarações

RC declares that he has no competing interests.

Dr Raul D. Santos, Dr Seth S. Martin, and Dr Rhanderson Cardoso would like to gratefully acknowledge Dr Martin Engelhardt and Dr Michael Miller, the previous contributors to this topic.

Declarações

ME declares that he has no competing interests. MM has received research grant support and honoraria for lectures from AstraZeneca, Merck-Schering Plough, and Pfizer. MM has received consulting fees from Pfizer, Merck-Schering Plough, and Roche.

RevisoresVER TUDO

Assistant Professor of Medicine

Noninvasive Cardiology

MetroHealth Campus

Case Western Reserve University

Cleveland

OH

Declarações

MLA declares that he has no competing interests.

Consultant/Senior Lecturer in Diabetes & Metabolism

The Royal Oldham Hospital & University of Manchester Cardiovascular Research Group Diabetes Centre

Royal Oldham Hospital

Oldham

UK

Declarações

DB declares that he has no competing interests.

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