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Hepatite A

  • Overview
  • Theory
  • Diagnosis
  • Management
  • Follow up
  • Resources
Last reviewed: 20 Aug 2025
Last updated: 20 May 2025

Summary

Definition

Анамнез и осмотр

Ключевые диагностические факторы

  • presença de fatores de risco
  • febre
  • mal-estar
  • náuseas e vômitos
  • icterícia
  • hepatomegalia
  • dor no quadrante superior direito
  • fezes com cor de argila
Полная информация

Другие диагностические факторы

  • fadiga
  • cefaleia
  • urina escura
  • prurido
  • artralgias e mialgias
  • tosse
  • diarreia
  • constipação
  • esplenomegalia
  • linfadenopatia cervical posterior
  • erupção cutânea evanescente
  • bradicardia
Полная информация

Факторы риска

  • pessoas que moram em regiões endêmicas
  • viagens a regiões endêmicas
  • contato pessoal próximo com uma pessoa infectada
  • homens que fazem sexo com homens
  • surto conhecido de doenças transmitidas por alimentos
  • uso de drogas ilícitas
  • desabrigo
  • exposição ocupacional
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • transaminases séricas
  • bilirrubina sérica
  • ureia sanguínea
  • creatinina sérica
  • tempo de protrombina
  • anti-HAV imunoglobulina M (IgM)
Полная информация

Исследования, проведение которых нужно рассмотреть

  • imunoglobulina G (IgG) contra vírus da hepatite A (HAV)
  • detecção do ácido ribonucleico (RNA) do vírus da hepatite A
Полная информация

Алгоритм лечения

Начальные

pessoas não vacinadas com exposição recente à hepatite A (<2 semanas)

Острый

hepatite A confirmada

Составители

Авторы

Doan Y Dao, MD

Assistant Professor of Medicine

Director, Center of Excellence for Liver Disease in Vietnam

Johns Hopkins School of Medicine

Department of Medicine

Division of GI and Hepatology

Baltimore MD

Раскрытие информации

DYD receives grants from Roche Diagnostics International Ltd and Gilead Sciences.

Выражение благодарностей

Dr Doan Dao would like to gratefully acknowledge Dr Musaddiq Waheed and the late Dr Fida A. Khan, the previous contributors to this topic.

Раскрытие информации

MW and FAK declared that they have no competing interests.

Рецензенты

Howard J. Worman, MD

Professor of Medicine and Cell Biology

Columbia University College of Physicians and Surgeons

New York

NY

Disclosures

HJW declares that he has no competing interests.

Srikrishna Nagri, MD

Gastroenterologist

Dartmouth-Hitchcock Nashua

Nashua

NH

Disclosures

SN declares that he has no competing interests.

George Y. Wu, MD, PhD

Professor of Medicine

University of Connecticut Health Center

Farmington

CT

Disclosures

GYW is on the medical advisory boards of the following: Gilead Sciences, Bristol-Myers Squibb, AbbVie, and Intercept.

Kittichai Promrat, MD

Assistant Professor

Division of Gastroenterology

Department of Medicine

Brown University

RI

Disclosures

KP declares that he has no competing interests.

Pierre Van Damme, MD, PhD

Professor

Director of Vaccine & Infectious Disease Institute

University of Antwerp

Antwerp

Belgium

Disclosures

PVD has been and still is principal investigator of vaccine trials for several vaccine manufacturing companies, from which the university obtained and obtains research contracts and funds for conducting such vaccine trials.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Centers for Disease Control and Prevention. Hepatitis A. [internet publication].Full text

Kemmer NM, Miskovsky EP. Hepatitis A. Infect Dis Clin North Am. 2000 Sep;14(3):605-15. Abstract

Nelson NP, Weng MK, Hofmeister MG, et al. Prevention of hepatitis A virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep. 2020 Jul 3;69(5):1-38.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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