Summary
Definition
History and exam
Key diagnostic factors
- presença de fatores de risco
- febre
- mal-estar
- náuseas e vômitos
- icterícia
- hepatomegalia
- dor no quadrante superior direito
- fezes com cor de argila
Other diagnostic factors
- fadiga
- cefaleia
- urina escura
- prurido
- artralgias e mialgias
- tosse
- diarreia
- constipação
- esplenomegalia
- linfadenopatia cervical posterior
- erupção cutânea evanescente
- bradicardia
Risk factors
- pessoas que moram em regiões endêmicas
- viagens a regiões endêmicas
- contato pessoal próximo com uma pessoa infectada
- homens que fazem sexo com homens
- surto conhecido de doenças transmitidas por alimentos
- uso de drogas ilícitas
- desabrigo
- exposição ocupacional
Diagnostic tests
1st tests to order
- transaminases séricas
- bilirrubina sérica
- ureia sanguínea
- creatinina sérica
- tempo de protrombina
- anti-HAV imunoglobulina M (IgM)
Tests to consider
- imunoglobulina G (IgG) contra vírus da hepatite A (HAV)
- detecção do ácido ribonucleico (RNA) do vírus da hepatite A
Treatment algorithm
pessoas não vacinadas com exposição recente à hepatite A (<2 semanas)
hepatite A confirmada
Contributors
Authors
Doan Y Dao, MD
Assistant Professor of Medicine
Director, Center of Excellence for Liver Disease in Vietnam
Johns Hopkins School of Medicine
Department of Medicine
Division of GI and Hepatology
Baltimore MD
Disclosures
DYD receives grants from Roche Diagnostics International Ltd and Gilead Sciences.
Acknowledgements
Dr Doan Dao would like to gratefully acknowledge Dr Musaddiq Waheed and the late Dr Fida A. Khan, the previous contributors to this topic.
Disclosures
MW and FAK declared that they have no competing interests.
Peer reviewers
Howard J. Worman, MD
Professor of Medicine and Cell Biology
Columbia University College of Physicians and Surgeons
New York
NY
Disclosures
HJW declares that he has no competing interests.
Srikrishna Nagri, MD
Gastroenterologist
Dartmouth-Hitchcock Nashua
Nashua
NH
Disclosures
SN declares that he has no competing interests.
George Y. Wu, MD, PhD
Professor of Medicine
University of Connecticut Health Center
Farmington
CT
Disclosures
GYW is on the medical advisory boards of the following: Gilead Sciences, Bristol-Myers Squibb, AbbVie, and Intercept.
Kittichai Promrat, MD
Assistant Professor
Division of Gastroenterology
Department of Medicine
Brown University
RI
Divulgaciones
KP declares that he has no competing interests.
Pierre Van Damme, MD, PhD
Professor
Director of Vaccine & Infectious Disease Institute
University of Antwerp
Antwerp
Belgium
Divulgaciones
PVD has been and still is principal investigator of vaccine trials for several vaccine manufacturing companies, from which the university obtained and obtains research contracts and funds for conducting such vaccine trials.
Agradecimiento de los revisores por pares
Los temas de BMJ Best Practice se actualizan de forma continua de acuerdo con los desarrollos en la evidencia y en las guías. Los revisores por pares listados aquí han revisado el contenido al menos una vez durante la historia del tema.
Divulgaciones
Las afiliaciones y divulgaciones de los revisores por pares se refieren al momento de la revisión.
Referencias
Artículos principales
Centers for Disease Control and Prevention. Hepatitis A. [internet publication].Texto completo
Kemmer NM, Miskovsky EP. Hepatitis A. Infect Dis Clin North Am. 2000 Sep;14(3):605-15. Resumen
Nelson NP, Weng MK, Hofmeister MG, et al. Prevention of hepatitis A virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices, 2020. MMWR Recomm Rep. 2020 Jul 3;69(5):1-38.Texto completo Resumen
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
Diferenciales
- Hepatite B aguda
- Hepatite E
- Hepatite C aguda
Más DiferencialesGuías de práctica clínica
- Hepatitis A
- Child and adolescent immunization schedule by age: recommendations for ages 18 years or younger, United States, 2025
Más Guías de práctica clínica
Inicie sesión o suscríbase para acceder a todo el BMJ Best Practice
El uso de este contenido está sujeto a nuestra cláusula de exención de responsabilidad