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Mononucleose infecciosa

  • Visão geral
  • Teoria
  • Diagnóstico
  • Tratamento
  • ACOMPANHAMENTO
  • Recursos
Última revisão: 14 Sep 2025
Última atualização: 16 Nov 2021

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • presença de fatores de risco
  • febre
  • faringite
  • linfadenopatia cervical ou generalizada
  • mal-estar
Detalhes completos

Outros fatores diagnósticos

  • esplenomegalia
  • erupção cutânea
  • sinais de hepatite (hepatomegalia, icterícia)
  • icterícia
  • mialgia
Detalhes completos

Fatores de risco

  • beijar
  • comportamento sexual
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • Hemograma completo
  • anticorpos heterófilos
  • Anticorpos específicos contra o vírus Epstein-Barr (EBV)
  • TFHs
Detalhes completos

Investigações a serem consideradas

  • reação em cadeia da polimerase em tempo real (RT-PCR)
  • ultrassonografia do abdome
  • tomografia computadorizada (TC) do abdome
Detalhes completos

Algoritmo de tratamento

AGUDA

todos os pacientes

Colaboradores

Autores

George Turabelidze, MD, PhD

Medical Epidemiologist

Missouri Department of Health and Senior Services

Adjunct Assistant Professor of Clinical Pediatrics

Washington University School of Medicine

St Louis

MO

Disclosures

GT declares that he has no competing interests.

Peer reviewers

Linda Kalilani, MBBS, MPhil, PhD

Epidemiologist

College of Medicine

University of Malawi

Zomba

Malawi

Disclosures

LK declares that she has no competing interests.

Paul G. Auwaerter, MD, MBA, FACP, FIDSA

Clinical Director

Division of Infectious Diseases

Associate Professor of Medicine

Divisions of Infectious Diseases and General Internal Medicine

Johns Hopkins University School of Medicine

Baltimore

MD

Disclosures

PGA declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Vetsika EK, Callan M. Infectious mononucleosis and Epstein-Barr virus. Expert Rev Mol Med. 2004 Nov 5;6(23):1-16. Abstract

Katz BZ. Update on chronic fatigue syndrome and Epstein-Barr virus. Pediatr Ann. 2002 Nov;31(11):741-4. Abstract

Ganzel TM, Goldman JL, Padhya TA. Otolaryngologic clinical patterns in pediatric infectious mononucleosis. Am J Otolaryngol. 1996 Nov-Dec;17(6):397-400. Abstract

De Paor M, O'Brien K, Fahey T, et al. Antiviral agents for infectious mononucleosis (glandular fever). Cochrane Database Syst Rev. 2016 Dec 8;(12):CD011487.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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