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Mononucleose infecciosa

  • Overview
  • Theory
  • Diagnosis
  • Management
  • Follow up
  • Resources
Evidence last reviewed: 20 Sep 2026
Topic last updated: 24 Jul 2026

Summary

Definition

History and exam

Key diagnostic factors

  • presença de fatores de risco
  • febre
  • faringite
  • linfadenopatia cervical ou generalizada
  • mal-estar
Full details

Other diagnostic factors

  • mialgia
  • esplenomegalia
  • erupção cutânea
  • sinais de hepatite (hepatomegalia, icterícia)
Full details

Risk factors

  • beijar
  • comportamento sexual
Full details

Diagnostic tests

1st tests to order

  • Hemograma completo
  • anticorpos heterófilos
  • Anticorpos específicos contra o vírus Epstein-Barr (EBV)
  • TFHs
Full details

Tests to consider

  • reação em cadeia da polimerase em tempo real (RT-PCR)
  • ultrassonografia do abdome
  • tomografia computadorizada (TC) do abdome
Full details

Treatment algorithm

ACUTE

todos os pacientes

Contributors

Authors

George Turabelidze, MD, PhD

Medical Epidemiologist

Missouri Department of Health and Senior Services

Adjunct Assistant Professor of Clinical Pediatrics

Washington University School of Medicine

St Louis, MO

Disclosures

GT declares that he has no competing interests.

Peer reviewers

Ben Z. Katz , MD

Professor of Pediatrics

Northwestern University

Feinberg School of Medicine

Attending Physician

Division of Infectious Diseases

Ann & Robert H Lurie Children’s Hospital of Chicago

Chicago, IL

Disclosures

BZK declares that he has no competing interests.

Linda Kalilani, MBBS, MPhil, PhD

Epidemiologist

College of Medicine

University of Malawi

Zomba

Malawi

Disclosures

LK declares that she has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Ganzel TM, Goldman JL, Padhya TA. Otolaryngologic clinical patterns in pediatric infectious mononucleosis. Am J Otolaryngol. 1996 Nov-Dec;17(6):397-400. Abstract

De Paor M, O'Brien K, Fahey T, et al. Antiviral agents for infectious mononucleosis (glandular fever). Cochrane Database Syst Rev. 2016 Dec 8;(12):CD011487.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

  • Differentials

    • Faringite por estreptococo do grupo A
    • Escarlatina
    • Hepatite A
    More Differentials

  • Guidelines

    • Laboratory testing for Epstein-Barr virus (EBV)
    • Clinical overview of Epstein-Barr virus (EBV)
    More Guidelines

  • Patient information

    Febre glandular (mononucleose infecciosa)

    More Patient information

  • Videos

    Venopunção e flebotomia – Vídeo de demonstração

    Canulação venosa periférica – Vídeo de demonstração

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