Summary
Definition
History and exam
Key diagnostic factors
- presença de fatores de risco
- febre
- rubor na pele/erupção cutânea
- mialgia/artralgia/cefaleia
- sinais hemorrágicos
- letargia/inquietação
- hepatomegalia
- distensão abdominal
- dor torácica pleurítica, dispneia, tosse
- sinais de colapso circulatório
Other diagnostic factors
- sintomas gastrointestinais
- sintomas no trato respiratório superior
Risk factors
- residência/viagem a região endêmica de dengue nas últimas 2 semanas
- crianças de 1 a 5 anos de idade
- idade avançada
- gestação
- presença de comorbidades
- exposição a hemoderivados infectados
- viver com recipiente de água descoberto
- sexo feminino
- obesidade
- grupo sanguíneo O
Diagnostic investigations
1st investigations to order
- Hemograma completo
- testes da função hepática
- nível de albumina sérica
- sorologia
- reação em cadeia da polimerase via transcriptase reversa (RT-PCR)
- detecção de proteína não estrutural 1 (NS1)
Investigations to consider
- exames de coagulação
- radiografia torácica
- ultrassonografia abdominal
Emerging tests
- reação em cadeia da polimerase isotérmica isolada de transcrição reversa (RT-iiPCR)
Treatment algorithm
Grupo C da Organização Mundial da Saúde (OMS) (sinais de alerta estabelecidos)
Grupo B da Organização Mundial da Saúde (OMS) (desenvolvendo sinais de alerta)
Grupo A da Organização Mundial da Saúde (OMS) (sem sinais de alerta)
Contributors
Authors
S.A.M. Kularatne, MBBS, MD, MRCP (UK), FRCP (London), FCCP (SL)
Senior Professor
Chair of Medicine
Department of Medicine
Faculty of Medicine
University of Peradeniya
Peradeniya
Sri Lanka
Disclosures
SAMK is an author of several references cited in this topic.
Peer reviewers
John McBride, PhD, MBBS, DTM&H, FRACP, FRCPA
Professor of Medicine
James Cook University
Cairns Base Hospital Clinical School
Cairns
Australia
Disclosures
JM declares that he has no competing interests.
Michael Jacobs, MA, PhD, MBBS, FRCP, DTM&H
Consultant
Infectious Diseases
Royal Free Hampstead NHS Trust
London
UK
Disclosures
MJ declares that he has no competing interests.
Stephen Gluckman, MD
Professor of Medicine
Medical Director
Penn Global Medicine
Penn Center for Primary Care
PA
Disclosures
SG declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
World Health Organization, Regional Office for South-East Asia. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever - revised and expanded edition. 2011 [internet publication].Full text
World Health Organization, Special Programme for Research and Training in Tropical Diseases (TDR). Dengue: guidelines for diagnosis, treatment, prevention and control. New edition. 2009 [internet publication].Full text
Guo C, Zhou Z, Wen Z, et al. Global epidemiology of dengue outbreaks in 1990-2015: a systematic review and meta-analysis. Front Cell Infect Microbiol. 2017 Jul 12;7:317.Full text Abstract
Simmons CP, Farrar JJ, Nguyen VV, et al. Dengue. N Engl J Med. 2012;366:1423-1432. Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Infecção pelo vírus da Zika
- Infecção pelo vírus da chikungunya
- Doenças por rickettsias
More DifferentialsGuidelines
- CDC Yellow Book: health information for international travel - dengue
- Laboratory testing for Zika virus and dengue virus infections
More GuidelinesPatient information
Febre da dengue
More Patient informationVideos
Venopunção e flebotomia – Vídeo de demonstração
Canulação venosa periférica – Vídeo de demonstração
More videos
Log in or subscribe to access all of BMJ Best Practice
Use of this content is subject to our disclaimer