Summary
Definition
History and exam
Key diagnostic factors
- história familiar
- história de exposição a asbesto
- idade entre 60 e 85 anos
- dispneia
- murmúrio vesicular diminuído
- macicez à percussão
Other diagnostic factors
- sexo masculino
- dor torácica
- tosse
- sintomas constitucionais
- distensão e/ou dor abdominal
Risk factors
- exposição ao asbesto
- idade entre 60 e 85 anos
- exposição ao asbesto durante a reforma e manutenção de casas
- sexo masculino
- exposição à radiação
- predisposição genética
- vírus símio 40 (SV-40)
Diagnostic tests
1st tests to order
- radiografia torácica
- TC do tórax e abdome superior (com contraste)
Tests to consider
- toracocentese
- tomografia por emissão de pósitrons/tomografia computadorizada (PET/TC)
- biópsia pleural
- cirurgia toracoscópica videoassistida (CTVA)
- imuno-histoquímica
- Teste de linha germinativa
- ressonância nuclear magnética (RNM) do tórax
- mediastinoscopia cervical
- testes de função pulmonar
- Hemograma completo
- perfil metabólico básico
Emerging tests
- biomarcadores diagnósticos
Treatment algorithm
doença ressecável
doença irressecável ou recorrente
Contributors
Authors
Hedy Kindler, MD
Professor of Medicine
Associate Dean for Clinical Science Research, Human Subjects
The University of Chicago, Biological Sciences Division
Section of Hematology/Oncology
Chicago
Раскрытие информации
HK declares she has no competing interests.
Выражение благодарностей
Dr Hedy Kindler would like to gratefully acknowledge Dr Idrees Mian, Dr Jaydira del Rivero, Dr Anish Thomas, Mrs Mary Hesdorffer, Dr Robert Taub, and Dr Chris R. Kelsey, the previous contributors to this topic.
Раскрытие информации
IM, JdR, AT, MH, RT, and CRK declare that they have no competing interests.
Рецензенты
Marc de Perrot, MD, MSc
Associate Professor of Surgery
University of Toronto
Division of Thoracic Surgery
Toronto General Hospital
Ontario
Canada
Раскрытие информации
MdP is an author of a reference cited in this topic.
Tom Treasure, MD, MS FRCS, FRCP
Professor of Cardiothoracic Surgery (Honorary)
Clinical Operational Research Unit
Department of Mathematics
University College London
London
UK
Раскрытие информации
TT is an author of a reference cited in this topic.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Список литературы
Основные статьи
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: mesothelioma: pleural [internet publication].Полный текст
Woolhouse I, Bishop L, Darlison L, et al. British Thoracic Society guideline for the investigation and management of malignant pleural mesothelioma. Thorax. 2018 Mar;73(suppl 1):i1-30.Полный текст Аннотация
Popat S, Baas P, Faivre-Finn C, et al. Malignant pleural mesothelioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2022 Feb;33(2):129-42.Полный текст Аннотация
Kindler HL, Ismaila N, Bazhenova L, et al. Treatment of pleural mesothelioma: ASCO guideline update. J Clin Oncol. 2025 Mar 10;43(8):1006-38.Полный текст Аннотация
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Hiperplasia mesotelial reativa benigna
- Reações pleurais benignas relacionadas ao asbesto
- Câncer pulmonar de células não pequenas
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