Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- presença de fatores de risco
- eritema e/ou ulceração da mucosa oral
- dor oral
Outros fatores diagnósticos
- sangramento intraoral
- comprometimento alimentar e/ou perda de peso
- diarreia
- náuseas e/ou vômitos
- dor abdominal
- febre
Fatores de risco
- esquemas de quimioterapia intensiva
- radioterapia na cavidade oral
- quimiorradiação
- polimorfismos genéticos em enzimas metabólicas do medicamento
- uso de terapias direcionadas e imunoterapias
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- diagnóstico clínico
Investigações a serem consideradas
- Hemograma completo com diferencial
- hemoculturas
- esfregaço superficial da lesão para microscopia
- cultura fúngica
- cultura viral ou reação em cadeia da polimerase
Algoritmo de tratamento
pacientes submetidos a transplante de células-tronco hematopoéticas: medidas preventivas
pacientes que recebem fluoruracila em bolus: medidas preventivas
pacientes que recebem radioterapia na cavidade oral: medidas preventivas
mucosite oral estabelecida
Colaboradores
Autores
Ourania Nicolatou-Galitis, DDS, MSc, DrDent
Dentist
Specialist in Oral Medicine and Oral Oncology
Hospital Dentistry
National & Kapodistrian University of Athens
Athens
Greece
Declarações
ONG has received fees from Angelini pharma to author a review article on oral mucositis and is the co-founder and scientific responsible of mycancer, a startup private company which aims to provide a comprehensive medical platform for cancer patients. ONG is an author of several references cited in this topic.
Nikolaos Tsoukalas, MD, MSc, PhD
Medical Oncologist
Associate Director
Department of Oncology
401 General Military Hospital
Athens
Greece
Declarações
NT declares that he has no competing interests.
Agradecimentos
Professor Ourania Nicolatou-Galitis and Dr Nikolaos Tsoukalas would like to gratefully acknowledge Dr Eleni Arvanitou, who contributed to the updating of this topic, and Dr Rajesh V. Lalla, a previous contributor.
Declarações
EA declares that she has no competing interests. RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics, and Novartis.
Revisores
Michael Brennan, DDS, MHS
Associate Chairman and Oral Medicine Residency Director
Department of Oral Medicine
Carolinas Medical Center
Charlotte
NC
Declarações
MB is an author of a reference cited in this topic. MB is part of the Mucositis Study Group of MASCC/ISOO, and participated in the review of mucositis.
Maria Michelagnoli, MB ChB, MD, FRCPCH
Consultant Pediatric and Adolescent Oncologist
University College London Hospitals
London
UK
Declarações
MM declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Referências
Principais artigos
Elad S, Cheng KKF, Lalla RV, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2020 Oct 1;126(19):4423-31.Texto completo Resumo
Peterson DE, Boers-Doets CB, Bensadoun RJ, et al; ESMO Guidelines Committee. Management of oral and gastrointestinal mucosal injury: ESMO clinical practice guidelines for diagnosis, treatment, and follow-up. Ann Oncol. 2015 Sep;26(suppl 5):v139-51.Texto completo Resumo
Artigos de referência
Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
Diagnósticos diferenciais
- Candidíase oral
- Infecção pelo vírus do herpes simples
- Doença do enxerto contra o hospedeiro
Mais Diagnósticos diferenciaisDiretrizes
- MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy
- Oral management guidance
Mais Diretrizes
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