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Mucosite oral

  • Обзор
  • Теория
  • Диагноз
  • Лечение
  • Последующее наблюдение
  • Источники
Последний просмотренный: 11 Aug 2025
Last updated: 28 Feb 2025

Резюме

Определение

Анамнез и осмотр

Ключевые диагностические факторы

  • presença de fatores de risco
  • eritema e/ou ulceração da mucosa oral
  • dor oral
Полная информация

Другие диагностические факторы

  • sangramento intraoral
  • comprometimento alimentar e/ou perda de peso
  • diarreia
  • náuseas e/ou vômitos
  • dor abdominal
  • febre
Полная информация

Факторы риска

  • esquemas de quimioterapia intensiva
  • radioterapia na cavidade oral
  • quimiorradiação
  • polimorfismos genéticos em enzimas metabólicas do medicamento
  • uso de terapias direcionadas e imunoterapias
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • diagnóstico clínico
Полная информация

Исследования, проведение которых нужно рассмотреть

  • Hemograma completo com diferencial
  • hemoculturas
  • esfregaço superficial da lesão para microscopia
  • cultura fúngica
  • cultura viral ou reação em cadeia da polimerase
Полная информация

Алгоритм лечения

Начальные

pacientes submetidos a transplante de células-tronco hematopoéticas: medidas preventivas

pacientes que recebem fluoruracila em bolus: medidas preventivas

pacientes que recebem radioterapia na cavidade oral: medidas preventivas

Острый

mucosite oral estabelecida

Составители

Авторы

Ourania Nicolatou-Galitis, DDS, MSc, DrDent

Dentist

Specialist in Oral Medicine and Oral Oncology

Hospital Dentistry

National & Kapodistrian University of Athens

Athens

Greece

Раскрытие информации

ONG has received fees from Angelini pharma to author a review article on oral mucositis and is the co-founder and scientific responsible of mycancer, a startup private company which aims to provide a comprehensive medical platform for cancer patients. ONG is an author of several references cited in this topic.

Nikolaos Tsoukalas, MD, MSc, PhD

Medical Oncologist

Associate Director

Department of Oncology

401 General Military Hospital

Athens

Greece

Раскрытие информации

NT declares that he has no competing interests.

Выражение благодарностей

Professor Ourania Nicolatou-Galitis and Dr Nikolaos Tsoukalas would like to gratefully acknowledge Dr Eleni Arvanitou, who contributed to the updating of this topic, and Dr Rajesh V. Lalla, a previous contributor.

Раскрытие информации

EA declares that she has no competing interests. RVL serves as a consultant for Galera Therapeutics, Ingalfarma, Mundipharma and Sucampo Pharma, and has received research funding from Onxeo, Sucampo Pharma, Galera Therapeutics, and Novartis.

Рецензенты

Michael Brennan, DDS, MHS

Associate Chairman and Oral Medicine Residency Director

Department of Oral Medicine

Carolinas Medical Center

Charlotte

NC

Раскрытие информации

MB is an author of a reference cited in this topic. MB is part of the Mucositis Study Group of MASCC/ISOO, and participated in the review of mucositis.

Maria Michelagnoli, MB ChB, MD, FRCPCH

Consultant Pediatric and Adolescent Oncologist

University College London Hospitals

London

UK

Раскрытие информации

MM declares that she has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Основные статьи

Elad S, Cheng KKF, Lalla RV, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2020 Oct 1;126(19):4423-31.Полный текст  Аннотация

Peterson DE, Boers-Doets CB, Bensadoun RJ, et al; ESMO Guidelines Committee. Management of oral and gastrointestinal mucosal injury: ESMO clinical practice guidelines for diagnosis, treatment, and follow-up. Ann Oncol. 2015 Sep;26(suppl 5):v139-51.Полный текст  Аннотация

Статьи, указанные как источники

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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