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Câncer pulmonar de células pequenas

Last reviewed: 29 Jun 2025
Last updated: 29 Apr 2025

Summary

Definition

History and exam

Key diagnostic factors

  • presença de fatores de risco
  • tosse
  • dispneia
  • hemoptise
  • dor torácica
  • perda de peso
Full details

Other diagnostic factors

  • idade entre 65 e 74 anos
  • sexo masculino
  • fadiga
  • anormalidades observadas no exame pulmonar
  • rouquidão
  • confusão
  • alterações da personalidade
  • náuseas e vômitos
  • cefaleia
  • disfagia
  • dor óssea e/ou fraturas
  • convulsões
  • adenopatia cervical ou supraclavicular
  • edema facial
  • veias dilatadas no pescoço ou na parede torácica/abdominal
  • baqueteamento digital
  • osteoartropatia hipertrófica
Full details

Risk factors

  • tabagismo
  • exposição ambiental ao tabaco
  • exposição ao gás radônio
  • exposição ao asbesto
Full details

Diagnostic investigations

1st investigations to order

  • radiografia torácica
  • TC do tórax, do fígado e das glândulas adrenais
Full details

Investigations to consider

  • broncoscopia
  • biópsia
  • toracocentese
  • toracoscopia
  • ressonância nuclear magnética (RNM) ou TC cranioencefálica
  • mediastinoscopia
  • tomografia por emissão de pósitrons com fluordesoxiglucose (FDG-PET-CT)
  • cintilografia óssea
  • aspirado e biópsia de medula óssea
  • Hemograma completo
  • TFHs
  • sódio sérico
  • função renal
  • testes da função pulmonar
Full details

Treatment algorithm

ACUTE

na apresentação inicial: doença limitada

na apresentação inicial: doença extensa

ONGOING

recidiva dentro de 6 meses

recidiva após 6 meses

Contributors

Authors

Bingnan Zhang, MD, MBA

Assistant Professor

Department of Thoracic/Head and Neck Medical Oncology

Division of Cancer Medicine

The University of Texas MD Anderson Cancer Center

Houston

TX

Disclosures

BZ declares that she has no competing interests.

Acknowledgements

Dr Bingnan Zhang would like to gratefully acknowledge Dr Leena Gandhi, Dr Alvin R. Cabrera, Dr Christopher R. Kelsey, Dr Lawrence B. Marks, Dr Rebecca Suk Heist, and Dr Catherine B. Meador, previous contributors to this topic.

Disclosures

LG, ARC, CRK, and LBM declare that they have no competing interests. RSH has received honouraria for consulting from Novartis, Abbvie, Daichii Sankyo, and EMD Serono. RSH's institution (not RSH) has received research funding from Agios, Abbvie, Exelixis, Daichii Sankyo, Novartis, Lilly, Mirati, Corvus, Incyte, and Genentech Roche.

Peer reviewers

Alan Neville, MD

Professor

Assistant Dean

Undergraduate Program

McMaster University

Hamilton

Ontario

Canada

Disclosures

AN declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: small cell lung cancer [internet publication].Full text

Dingemans AC, Früh M, Ardizzoni A, et al. Small-cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. Jul 2021;32(7):839-53.Full text  Abstract

Simone CB 2nd, Bogart JA, Cabrera AR, et al. Radiation therapy for small cell lung cancer: an ASTRO clinical practice guideline. Pract Radiat Oncol. 2020 May - Jun;10(3):158-73.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
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