Avaliação da pancitopenia

Last reviewed: 21 Jul 2025
Last updated: 23 Jul 2025

Summary

Differentials

Common

  • Quimioterapia
  • Radioterapia
  • Deficiência de vitamina B12
  • Deficiência de ácido fólico
  • Infiltração da medula óssea por neoplasia não hematológica
  • Linfoma não Hodgkin
  • Leucemia de células pilosas
  • Leucemia linfocítica crônica
  • Mielodisplasia
  • Cirrose
  • Hepatite B
  • Hepatite C
  • Hepatite autoimune
  • vírus da imunodeficiência humana (HIV)
  • Infecção por citomegalovírus
  • Infecção micobacteriana
Full details

Uncommon

  • Leucemia mieloide aguda
  • Leucemia linfoide aguda (LLA)
  • Mieloma múltiplo
  • Mielofibrose
  • Doenças do armazenamento lisossomal
  • Anorexia nervosa
  • Doença do enxerto contra o hospedeiro (DECH)
  • Intoxicação por metais pesados (arsênico)
  • Infecção por parvovírus em anemia falciforme (e outras anemias hemolíticas)
  • Disceratose congênita (DC):
  • Hemoglobinúria paroxística noturna (HPN)
  • Anemia aplásica idiopática
  • anemia de Fanconi
  • Outras citopenias hereditárias raras (por exemplo, anemia de Diamond-Blackfan, síndrome de Shwachman-Diamond e trombocitopenia amegacariocítica)
  • Hipertensão portal idiopática
  • Leucemia mieloide crônica
  • Brucelose
  • Leishmaniose
  • Síndromes hemofagocíticas
  • Pancitopenia imune induzida por medicamentos
  • Síndrome de Evans com neutropenia associada
  • Síndrome linfoproliferativa autoimune (SLPA)
  • Lúpus eritematoso sistêmico
  • Artrite reumatoide
  • Mononucleose infecciosa
  • Síndrome de Felty
Full details

Contributors

Authors

Jeffrey M. Lipton, MD, PhD

Frances and Thomas Gambino Professor of Pediatrics in Hematology/Oncology

Professor of Pediatrics and Molecular Medicine

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Professor, The Center for Autoimmune Musculoskeletal and Hematopoietic Diseases

Feinstein Institute for Medical Research

Director, Hematology/Oncology and Stem Cell Transplantation

Cohen Children's Medical Center of New York

Hyde Park

New York

Disclosures

JML has been reimbursed by Chiesi Farmaceutici S.p.A as a consultant.

Acknowledgements

Dr Jeffrey M. Lipton would like to gratefully acknowledge Dr Jeff K. Davies and Dr Eva C. Guinan, the previous contributors to this topic.

Disclosures

JKD and ECG declare that they have no competing interests.

Peer reviewers

Stella Davies, MD, PhD

Professor and Division Director

Cincinnati Children's Hospital Medical Center

Cincinnati

OH

Disclosures

SD declares that she has no competing interests.

Drew Provan, BSc, MBChB

Consultant Hematologist

Department of Hematology

The Royal London Hospital

London

UK

Disclosures

DP was medical director at GlaxoSmithKline 2005-2006.

Alfred P. Gillio, MD

Director

Bone Marrow Failure Clinic

Tomorrows Children's Institute

Hackensack University Medical Center

Hackensack

NJ

Disclosures

APG declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Kulasekararaj A, Cavenagh J, Dokal I, et al. Guidelines for the diagnosis and management of adult aplastic anaemia: a British Society for Haematology guideline. Br J Haematol. 2024 Mar;204(3):784-804.Full text  Abstract

Young NS. Aplastic anemia. N Engl J Med. 2018 Oct 25;379(17):1643-56.Full text  Abstract

Williams DA, Bennett C, Bertuch A, et al. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): an initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC). Pediatr Blood Cancer. 2014 May;61(5):869-74.Full text  Abstract

Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022 Jul;36(7):1703-19.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Avaliação da pancitopenia images
  • Guidelines

    • Guidelines for the diagnosis and management of adult aplastic anaemia
    • The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms
    More Guidelines
  • Patient information

    Linfoma não Hodgkin

    Linfoma não Hodgkin: perguntas a fazer ao seu médico

    More Patient information
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