Resumen
Definición
Anamnesis y examen
Principales factores de diagnóstico
- sinus and facial pain
- eye pain, blurred vision
- proptosis
- cranial nerve palsies
- dry cough, with or without dyspnea
- skin nodules
Otros factores de diagnóstico
- fever
- periorbital cellulitis
- viscid, dark brown-black nasal discharge
- focal sensory/motor neurologic deficits and altered mental status
- necrotic eschar
- hemoptysis
- abdominal pain and distension
- gastrointestinal bleeding
- peritonitis
Factores de riesgo
- diabetes mellitus ± diabetic ketoacidosis
- hematologic malignancy
- neutropenia
- iron overload or use of deferoxamine
- use of corticosteroids
- hematopoietic and solid organ transplantation, graft-versus-host disease
- breakdown of skin and soft tissue
- malnutrition
- prematurity
- liver cirrhosis
Pruebas diagnósticas
Primeras pruebas diagnósticas para solicitar
- CBC
- basic metabolic profile
- ABG
- urinalysis
- serum ketone level
- CT sinuses and brain
- MRI sinuses and brain
- CT chest with contrast
- nasal endoscopy
- gastrointestinal endoscopy
Pruebas diagnósticas que deben considerarse
- bronchoscopy with bronchoalveolar lavage and/or transbronchial biopsy fungal culture
- histopathology of biopsy
- microbiology of biopsy
Pruebas emergentes
- polymerase chain reaction (PCR)
Algoritmo de tratamiento
suitable for surgery
unsuitable for surgery
treatment failure
Colaboradores
Autores
Rachana M. Palnitkar, MD
Infectious Diseases
Private Practice
Los Gatos
CA
Divulgaciones
RMP declares that she has no competing interests.
Michael Sands, MD, MPH & TM, FIDSA
Professor of Medicine
College of Medicine
University of Florida
Jacksonville
FL
Divulgaciones
MS declares that he has no competing interests.
Revisores por pares
Michail Lionakis, MD, ScD
Infectious Diseases Fellow
Laboratory of Molecular Immunology
National Institute of Allergy and Infectious Diseases
NIH
Bethesda
MD
Divulgaciones
ML declares that he has no competing interests.
Rachael Morris-Jones, PhD, FRCP, PCME
Dermatology Consultant and Honorary Senior Lecturer
Kings College Hospital
London
UK
Divulgaciones
RMJ declares that she has no competing interests.
Agradecimiento de los revisores por pares
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Divulgaciones
Las afiliaciones y divulgaciones de los revisores por pares se refieren al momento de la revisión.
Referencias
Artículos principales
Pham D, Howard-Jones AR, Sparks R, et al. Epidemiology, modern diagnostics, and the management of mucorales infections. J Fungi (Basel). 2023 Jun 12;9(6):659.Texto completo Resumen
Spellberg B, Edwards J Jr, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev. 2005 Jul;18(3):556-69.Texto completo Resumen
Centers for Disease Control and Prevention. Mucormycosis: clinical overview of mucormycosis. Apr 2024 [internet publication].Texto completo
Cornely OA, Alastruey-Izquierdo A, Arenz D, et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019 Dec;19(12):e405-21.Texto completo Resumen
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
Differentials
- Aspergillosis
- Bacterial sinusitis
- Bacterial periorbital cellulitis
Más DifferentialsGuidelines
- Global guideline for the diagnosis and management of mucormycosis
- Global guideline for the diagnosis and management of mucormycosis
Más Guidelines
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