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Yellow fever

最后审阅: 15 Nov 2025
最后更新: 10 Aug 2023

小结

定义

病史和体格检查

关键诊断因素

  • history of residence in, or recent travel to, endemic area
  • lack of yellow fever immunization
  • history of mosquito bite
  • fever
  • constitutional symptoms
  • conjunctival injection
  • relative bradycardia (Faget sign)
  • biphasic illness
  • hemorrhagic diathesis
  • signs of renal failure
  • signs of hepatic failure
  • jaundice
完整详情

其他诊断因素

  • hypotension
  • abdominal pain, vomiting, and lethargy
完整详情

危险因素

  • residence in, or recent travel to, endemic area
  • lack of immunization
  • mosquito bite
  • travel during rainy and early dry seasons
完整详情

诊断性检查

首要检查

  • CBC
  • liver function tests
  • coagulation screen
  • reverse transcription polymerase chain reaction (RT-PCR)
  • serology
完整详情

需考虑的检查

  • ECG
  • histopathology
完整详情

新兴检查

  • virus isolation
  • isothermal nucleic acid amplification assays

治疗流程

初步治疗

unidentified viral hemorrhagic fever

急症处理

confirmed yellow fever

撰稿人

作者

William A. Messer, MD, PhD

Associate Professor of Medicine

Department of Molecular Microbiology and Immunology

Division of Infectious Diseases

Oregon Health & Science University

Portland

OR

利益声明

WAM declares that he has no competing interests.

鸣谢

Dr William A. Messer would like to gratefully acknowledge Dr Philip A. Yeon and Dr Helmut Albrecht, previous contributors to this topic.

Disclosures

PAY and HA declares that he has no competing interests.

同行评议者

Carlos Franco-Paredes, MD, MPH

Assistant Professor

Emory University

TravelWell Clinic

Emory University Hospital Midtown

Atlanta

GA

利益声明

CFP declares that he has no competing interests.

Andrea K. Boggild, MSc, MD, DTMH, FRCPC

Clinical Assistant

Tropical Diseases Unit

Division of Infectious Diseases

Department of Medicine

Toronto General Hospital

University Health Network

Toronto

Canada

利益声明

AKB declares that she has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

参考文献

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

关键文献

World Health Organization. Yellow fever: fact sheet. May 2023 [internet publication].全文

Staples JE, Bocchini JA Jr, Rubin L; Centers for Disease Control and Prevention (CDC). Yellow fever vaccine booster doses: recommendations of the Advisory Committee on Immunization Practices, 2015. MMWR Morb Mortal Wkly Rep. 2015;64:647-650.全文  摘要

Pan American Health Organization; World Health Organization. Laboratory diagnosis of yellow fever virus infection. September 2018 [internet publication].全文

参考文献

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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