Summary
Definition
History and exam
Key diagnostic factors
- history of residence in, or recent travel to, endemic area
- lack of yellow fever immunization
- history of mosquito bite
- fever
- constitutional symptoms
- conjunctival injection
- relative bradycardia (Faget sign)
- biphasic illness
- hemorrhagic diathesis
- signs of renal failure
- signs of hepatic failure
- jaundice
Other diagnostic factors
- hypotension
- abdominal pain, vomiting, and lethargy
Risk factors
- residence in, or recent travel to, endemic area
- lack of immunization
- mosquito bite
- travel during rainy and early dry seasons
Diagnostic tests
1st tests to order
- CBC
- liver function tests
- coagulation screen
- reverse transcription polymerase chain reaction (RT-PCR)
- serology
Tests to consider
- ECG
- histopathology
Emerging tests
- virus isolation
- isothermal nucleic acid amplification assays
Treatment algorithm
unidentified viral hemorrhagic fever
confirmed yellow fever
Contributors
Authors
William A. Messer, MD, PhD
Associate Professor of Medicine
Department of Molecular Microbiology and Immunology
Division of Infectious Diseases
Oregon Health & Science University
Portland
OR
Declarações
WAM declares that he has no competing interests.
Agradecimentos
Dr William A. Messer would like to gratefully acknowledge Dr Philip A. Yeon and Dr Helmut Albrecht, previous contributors to this topic.
Disclosures
PAY and HA declares that he has no competing interests.
Revisores
Carlos Franco-Paredes, MD, MPH
Assistant Professor
Emory University
TravelWell Clinic
Emory University Hospital Midtown
Atlanta
GA
Divulgaciones
CFP declares that he has no competing interests.
Andrea K. Boggild, MSc, MD, DTMH, FRCPC
Clinical Assistant
Tropical Diseases Unit
Division of Infectious Diseases
Department of Medicine
Toronto General Hospital
University Health Network
Toronto
Canada
Divulgaciones
AKB declares that she has no competing interests.
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Referencias
Artículos principales
World Health Organization. Yellow fever: fact sheet. May 2023 [internet publication].Texto completo
Staples JE, Bocchini JA Jr, Rubin L; Centers for Disease Control and Prevention (CDC). Yellow fever vaccine booster doses: recommendations of the Advisory Committee on Immunization Practices, 2015. MMWR Morb Mortal Wkly Rep. 2015;64:647-650.Texto completo Resumen
Pan American Health Organization; World Health Organization. Laboratory diagnosis of yellow fever virus infection. September 2018 [internet publication].Texto completo
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
Diferenciales
- Dengue fever
- Malaria
- Zika virus infection
Más DiferencialesGuías de práctica clínica
- CDC Yellow Book: health information for international travel - yellow fever
- Laboratory diagnosis of yellow fever virus infection
Más Guías de práctica clínica
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