Retinal vein occlusion

Last reviewed: 26 Aug 2023
Last updated: 02 Dec 2022



History and exam

Key diagnostic factors

  • sudden, painless vision loss
  • optic nerve head edema
  • intraretinal hemorrhage
  • venous tortuosity and dilation
  • collateral vessel formation
More key diagnostic factors

Other diagnostic factors

  • age >65 years
  • neovascularization
  • vitreous hemorrhage
  • macular edema
  • floaters
  • painful, red eye
  • visual acuity
  • relative afferent pupillary defect
  • elevated intraocular pressure
Other diagnostic factors

Risk factors

  • atherosclerosis
  • systemic hypertension
  • diabetes mellitus
  • hyperlipidemia
  • history of smoking
  • cardiovascular disease
  • glaucoma
  • increased body mass index at 20 years of age
  • increased serum alpha-2 globulin
  • short axial length
  • activated protein C resistance
  • factor V Leiden
  • hypercoagulable state
  • protein S deficiency
  • antithrombin III deficiency
  • hyperhomocysteinemia
  • vasculitis
  • age >65 years
More risk factors

Diagnostic investigations

1st investigations to order

  • fluorescein angiogram for confirmation of diagnosis
More 1st investigations to order

Investigations to consider

  • fluorescein angiogram for assessment of complications
  • optical coherence tomography
  • electroretinography
More investigations to consider

Treatment algorithm


CRVO: uncomplicated

CRVO with macular edema

CRVO with neovascularization

BRVO or HRVO: uncomplicated

BRVO or HRVO with macular edema

BRVO or HRVO with neovascularization



Aziz A. Khanifar, MD
Aziz A. Khanifar

Vitreoretinal Surgeon

The Retina Group of Washington

Silver Spring



AAK has been reimbursed by Novartis and Genentech as a speaker.


Dr Aziz A. Khanifar would like to gratefully acknowledge Dr Sharon Fekrat, a previous contributor to this topic.


SF declares that she has no competing interests.

Peer reviewers

Stephen G. Schwartz, MD

Assistant Professor of Clinical Ophthalmology

Bascom Palmer Eye Institute

University of Miami Miller School of Medicine




SGS has received research funding from Alcon, Genentech, and Novartis; holds equity in Pfizer; and is co-holder of a patent pending entitled "Molecular targets for modulating intraocular pressure and differentiation of steroid responders from non-responders".

Tim Murray, MD

Professor of Ophthalmology

Bascom Palmer Eye Institute

University of Miami Miller School of Medicine




TM declares that he has no competing interests.

Alexander Spratt, MBBCh, MRCOphth

Specialist Registrar

Moorfields Eye Hospital

Visiting Lecturer

City University




AS has received research funding from Allergan.

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