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Wilms' tumour

Last reviewed: 2 Apr 2025
Last updated: 05 Apr 2023

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • upper abdominal/flank mass or swelling
Full details

Other diagnostic factors

  • abdominal distension
  • abdominal pain
  • hypertension
  • haematuria
  • poor appetite or weight loss
  • fever
  • pallor
  • shortness of breath
  • hepatomegaly
  • varicocele
  • hypoglycaemia in infancy
  • features of paraneoplastic syndrome
Full details

Risk factors

  • age <5 years
  • congenital urogenital anomalies
  • congenital syndromes
  • family history of Wilms' tumour
  • antenatal exposure to harmful environmental factors
Full details

Diagnostic investigations

1st investigations to order

  • FBC
  • renal function
  • liver function tests
  • urinalysis
  • serum total protein/albumin
  • coagulation studies
  • serum calcium level
  • abdominal ultrasound with Doppler
  • CT or MRI abdomen and pelvis with and without contrast
  • CT chest with and without contrast
  • chest x-ray
Full details

Investigations to consider

  • tumour histology
  • genetic testing
  • loss of heterozygosity (LOH) studies
Full details

Treatment algorithm

ACUTE

COG criteria

SIOP criteria

ONGOING

tumour recurrence

Contributors

Authors

Sandeep Batra, MD

Clinical Assistant Professor

Riley Hospital for Children

Department of Pediatrics

Indiana University School of Medicine

Indianapolis

IN

Disclosures

SB declares that he has no competing interests.

Peer reviewers

Nadine Deannie Lee, MD

Pediatric Hematologist-Oncologist

Hematology/Oncology

Riley Children's Hospital

Indiana University Health

Indianapolis

IN

Disclosures

NDL declares that she has no competing interests.

Norbert Graf, MD

Direktor

Klinik für Pädiatrische Onkologie und Hämatologie

Universitätsklinikum des Saarlandes

Homburg

Germany

Disclosures

NG declares that he has no competing interests.

Zelig Tochner, MD

Associate Professor

Radiation Oncology

Children's Hospital of Philadelphia

Philadelphia

PA

Disclosures

ZT declares that he has no competing interests.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Spreafico F, Fernandez CV, Brok J, et al. Wilms tumour. Nat Rev Dis Primers. 2021 Oct 14;7(1):75.Full text  Abstract

Lopyan NM, Ehrlich PF. Surgical management of Wilms tumor (nephroblastoma) and renal cell carcinoma in children and young adults. Surg Oncol Clin N Am. 2021 Apr;30(2):305-23. Abstract

Vujanić GM, Parsons LN, D'Hooghe E, et al. Pathology of Wilms' tumour in International Society of Paediatric Oncology (SIOP) and Children's Oncology Group (COG) renal tumour studies: similarities and differences. Histopathology. 2022 Jun;80(7):1026-37. Abstract

van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, et al. Position paper: rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol. 2017 Dec;14(12):743-52.Full text  Abstract

Dome JS, Mullen EA, Dix DB, et al. Impact of the first generation of Children's Oncology Group clinical trials on clinical practice for Wilms tumor. J Natl Compr Canc Netw. 2021 Aug 1;19(8):978-85.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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