Last reviewed: 22 May 2021
Last updated: 22 Jun 2021

Summary

Differentials

Common

  • Sepsis
  • Typhoid
  • Brucellosis
  • HIV
  • Hepatitis
  • Influenza
  • Infectious mononucleosis
  • Respiratory syncytial virus
  • Erythema infectiosum
  • Rickettsia
  • Drug-induced
  • Cytotoxic chemotherapy
  • Radiation therapy
  • Immune neutropenia
  • Acute myelogenous leukemia
  • Acute lymphocytic leukemia
  • Myelodysplastic syndrome
  • Chronic lymphocytic leukemia (CLL)
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Infiltration by secondary malignancy
  • Aplastic anemia
  • Vitamin B12/folate deficiency
  • Alcohol misuse

Uncommon

  • Cytomegalovirus
  • Rubella
  • Measles
  • Chicken pox
  • Human granulocytic ehrlichiosis
  • Malaria
  • Leishmaniasis
  • Transfusion reaction
  • Copper deficiency
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Sjogren syndrome
  • Felty syndrome
  • Increased neutrophil margination
  • Laboratory artifact
  • Bone marrow failure syndromes
  • Isolated neutropenia syndromes
  • Immunodeficiency syndromes
  • Inborn errors of metabolism

Contributors

Professor and Chairman

Department of Hematologic Oncology and Blood Disorders

Levine Cancer Institute

Carolinas HealthCare System

Charlotte

NC

Disclosures

EC is a member of the Amgen Executive Advisory Board.

Professor and Vice-Chair

Department of Hematologic Oncology and Blood Disorders

Levine Cancer Institute

Carolinas HealthCare System

Charlotte

NC

Disclosures

BA declares that she has no competing interests.

Assistant Professor

Hematologic Oncology and Blood Disorders

Levine Cancer Institute

Carolinas HealthCare System

Charlotte

NC

Disclosures

RF has been reimbursed by Amgen and Takeda Oncology for serving on the speakers' bureau for carfilzomib, xgeva, and ixazomib.

Dr Edward Copelan, Dr Belinda Avalos, and Dr Reed Friend would like to gratefully acknowledge Dr Lisa Sproat, the previous contributor to this topic.

Disclosures

LS declares that she has no competing interests.

Peer reviewersVIEW ALL

Professor of Paediatric Haematology

University of Leeds and Leeds Teaching Hospitals NHS Trust

St. James's University Hospital

Leeds

UK

Disclosures

SEK is a medical advisory board member of the Severe Chronic Neutropenia International Registry (not remunerated) and is an author of references cited in the topic including data from the registry. SEK has been in receipt of educational grants from Chugai Pharma.

Professor

Pediatric Hematology/Oncology

Associate Chair

Department of Pediatrics and Communicable Diseases

Henry and Mala Dorfman Family Professorship

Pediatric Hematology/Oncology

Ann Arbor

MI

Disclosures

LAB is an author of references cited in this topic. LAB declares that he has no competing interests.

SCNIR

DCC Europe

Medizinische Hochschule Hannover

Kinderklinik

Hannover

Germany

Disclosures

Not disclosed.

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