Резюме
Определение
Анамнез и осмотр
Ключевые диагностические факторы
- profuse watery diarrhea
Другие диагностические факторы
- age around 50 years
- headache
- weight loss
- poor skin turgor
- dry mucus membranes
- muscle weakness
- muscle cramps
- gastrointestinal symptoms
- hyperglycemia symptoms
- flushing
- hepatomegaly
- history of multiple endocrine neoplasia type 1 (MEN1)
Факторы риска
- multiple endocrine neoplasia type 1 (MEN1)
- age around 50 years
Диагностические исследования
Исследования, которые показаны в первую очередь
- serum potassium
- serum bicarbonate
- serum calcium
- serum glucose
- vasoactive intestinal peptide (VIP) radioimmunoassay
- liver function tests
Исследования, проведение которых нужно рассмотреть
- arterial blood gas analysis
- gastric pH monitoring
- chromogranin A
- pancreatic polypeptide
- contrast-enhanced CT scan of abdomen
- contrast-enhanced MRI of abdomen
- somatostatin receptor PET-CT/MRI
- somatostatin receptor scintigraphy
- endoscopic ultrasound
- operative exploration
- intraoperative ultrasound
- biopsy
Алгоритм лечения
initial presentation of symptomatic patient
localized disease
metastatic disease: surgical candidate
metastatic disease: nonsurgical candidate
refractory disease
Составители
Авторы
Harish Lavu, MD, FACS
Professor of Surgery
Sidney Kimmel Medical College
Thomas Jefferson University
Philadelphia, PA
Раскрытие информации
HL declares that he has no competing interests.
Charles J. Yeo, MD, FACS
The Samuel D. Gross Professor and Chair
Department of Surgery
Sidney Kimmel Medical College
Thomas Jefferson University
Philadelphia, PA
Раскрытие информации
CJY declares that he has no competing interests.
Рецензенты
Alexandria Phan, MD
Professor of Medicine
Froedtert Hospital and the Medical College of Wisconsin
Milwaukee, WI
Раскрытие информации
AP declares that she has no competing interests.
Jonathan Strosberg, MD
Professor
Moffitt Cancer Center
Tampa, FL
Раскрытие информации
JS has consulted for Novartis and serves on the Speakers’ Bureau for Ipsen.
Jaime Ruiz-Tovar, MD
Fellow of the Spanish Association of Surgeons (AEC)
Department of Surgery
University Hospital Ramon y Cajal
Madrid
Spain
Раскрытие информации
JRT declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Список литературы
Основные статьи
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors [internet publication].Полный текст
Hofland J, Falconi M, Christ E, et al. European Neuroendocrine Tumor Society 2023 guidance paper for functioning pancreatic neuroendocrine tumour syndromes. J Neuroendocrinol. 2023 Aug;35(8):e13318.Полный текст Аннотация
Pavel M, Öberg K, Falconi M, et al. Gastroenteropancreatic neuroendocrine neoplasms: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020 Jul;31(7):844-60.Полный текст
Del Rivero J, Perez K, Kennedy EB, et al. Systemic therapy for tumor control in metastatic well-differentiated gastroenteropancreatic neuroendocrine tumors: ASCO guideline. J Clin Oncol. 2023 Nov 10;41(32):5049-67.Полный текст Аннотация
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Infectious gastroenteritis
- Osmotic diarrhea
- Ileal bile acid malabsorption
Больше ОтличияРекомендации
- NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
- NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors
Больше Рекомендации
Войдите в учетную запись или оформите подписку, чтобы получить полноценный доступ к BMJ Best Practice
Использование этого контента попадает под действие нашего заявления об отказе от ответственности