Evaluation of proteinuria

Last reviewed: 4 Jun 2025
Last updated: 10 Jan 2024

Summary

Differentials

Common

  • Fever
  • Heavy physical exertion
  • Urinary tract infection
  • Urologic hemorrhage
  • Orthostatic proteinuria
  • Minimal change disease
  • Focal segmental glomerulosclerosis
  • Membranous nephropathy
  • Membranoproliferative glomerulonephritis
  • IgA nephropathy
  • Systemic lupus erythematosus
  • Postinfectious glomerulonephritis
  • Acute tubular injury
  • Interstitial nephritis
  • Urinary tract obstruction
  • Metabolic syndrome
  • Diabetic nephropathy
  • Hypertension
  • Medium- and small-vessel vasculitis
  • Rhabdomyolysis (myoglobinuria)
Full details

Uncommon

  • Pregnancy
  • Amyloidosis
  • Light and heavy chain deposition diseases
  • Fibrillary and immunotactoid glomerulopathy
  • Antiglomerular basement membrane (anti-GBM) disease (Goodpasture syndrome)
  • Fanconi syndrome
  • Cystic kidney disease
  • Hypercalciuria
  • Dent disease
  • Aristolochic acid nephropathy
  • Light chain cast nephropathy
  • Fabry disease
  • Hemolytic uremic syndrome (HUS)
  • Thrombotic thrombocytopenic purpura (TTP)
  • Scleroderma renal crisis
  • Heavy metal poisoning
  • Idiopathic nodular glomerulosclerosis
  • Proliferative glomerulonephritis with monoclonal IgG deposits
  • Polymyositis
  • Renal vein thrombosis
Full details

撰稿人

作者

Sana Waheed, MD

Staff Nephrologist

Piedmont Nephrology and Internal Medicine

Atlanta

GA

利益声明

SW declares that she has no competing interests.

鸣谢

Dr Sana Waheed would like to gratefully acknowledge Dr Derek M. Fine and Dr C. John Sperati, previous contributors to this topic.

利益声明

DMF is an author of a reference cited in this topic. CJS declares that he has no competing interests.

同行评议者

Mark Perazella, MD

Associate Professor

Yale University School of Medicine

New Haven

CT

利益声明

MP declares that he has no competing interests.

Arif Showkat, MD, FASN

Assistant Professor

Division of Nephrology

University of Tennessee

Memphis

TN

利益声明

AS declares that he has no competing interests.

Guy Neild, MD, FRCP, FRCPath

Professor of Nephrology

Institute of Urology and Nephrology

University College London

London

UK

利益声明

GN declares that he has no competing interests.

Frederick Tam, MBBS

Senior Lecturer in Renal Medicine

Division of Medicine

Imperial College London

UK

利益声明

FT has received travelling grants from Amgen, MSD, Novartis, and Roche to attend International Nephrology conferences. He has also received research grants from Wellcome Trust, Medical Research Council UK, Baxter Biosciences, and Roche Palo Alto. He has also provided consultancy to research work with GE Healthcare and Baxter Biosciences.

参考文献

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关键文献

Kidney Disease: Improving Global Outcomes. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Jan 2013 [internet publication].全文

National Institute for Health and Care Excellence. Chronic kidney disease in adults: assessment and management. Jan 2021 [internet publication].全文

参考文献

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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