Achalasia is an esophageal motor disorder characterized by a loss of esophageal peristalsis and failure of the lower esophageal sphincter to relax in response to swallowing.
The most common presenting symptoms are dysphagia to solids and liquids, regurgitation, and retrosternal pain. These can be slowly progressive over months or years.
The first investigation for any patient with dysphagia is usually endoscopy to exclude malignancy. Subsequent barium swallow studies and esophageal manometry are often required to establish the diagnosis of achalasia.
Treatment is symptomatic, not curative, and is primarily aimed at relieving dysphagia; options include pharmacologic, endoscopic, and surgical procedures.
Achalasia is an esophageal motor disorder of unknown etiology, characterized by esophageal aperistalsis and insufficient lower esophageal sphincter relaxation in response to swallowing. This results from loss of inhibitory nitrinergic neurons in the esophageal myenteric plexus.
History and exam
Key diagnostic factors
Other diagnostic factors
- posturing to aid swallowing
- retrosternal pressure/pain
- gradual weight loss
- slow eating
- coughing/choking while recumbent
- recurrent chest infections
- sensation of a lump in the throat (globus)
- herpes and measles viruses
- autoimmune disease
- HLA class II antigens
- consanguineous parents
- triple A (Allgrove) syndrome
1st investigations to order
- upper gastrointestinal endoscopy
- barium swallow
- high-resolution esophageal manometry
Investigations to consider
- chest x-ray
- radionucleotide esophageal emptying studies
- timed barium esophagogram
- CT chest
patients awaiting definitive treatment
good surgical candidate
poor surgical candidate
- Esophageal carcinoma
- Reflux esophagitis
- Connective tissue disorders (e.g., systemic sclerosis)
- American Society for Gastrointestinal Endoscopy guideline on informed consent for GI endoscopic procedures
- International Society for Diseases of the Esophagus achalasia guidelines
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